Immunology Lecture 1 Flashcards Preview

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Flashcards in Immunology Lecture 1 Deck (31):
1

What is a TNF?

has inflammatory effects (primary mediator of septic shock which causes vascular damage)

2

Why do we want to block TNF?

reduce inflammation

3

What is the purpose of cytokines and interleukins?

regulate immune response

4

IL-1

made by macrophages, stimulates T cells, B cells, liver cells, etc

5

IL-2

produced by T cells - T cell growth factor (can also stimulate B cells and macrophages)

6

IL-3

CSF stimulator

7

What is CSF?

Colony stimulating factor (induce the growth of bone marrow derived cells and differentiation)

8

IL-4

B cell growth factor (important in T-cell stimulation of B-lymphocytes)

9

IL-5

B cell growth factor, B cell differentiation factor, and eosinophil growth factor

10

IL-6

principal mediator of the acute phase response of inflammation

11

IL-10

stimulates the induction of TH-2 cytokines

12

IL-12

stimulates TH1 responses

13

IL-17

involved in inflammation

14

What are inferferons??

interfere with viruses - non virally infected cells are protected from viruses - stimulate macrophages, T cell, B cells, NK cells

15

What is an NK cell?

lymphocyte - kills tumor cells and some virally infected cells without specificity

16

What is a cytotoxic T-cell?

regulation of the immune response (CD8) - antigen specific - restricted to killing cells that have self antigen in addition to foreign antigen

17

What is a lymphocyte?

B and T cells

18

What is a monocyte?

circulating precursor cell to macrophage

19

What is a dendritic cell?

activation of T cells and initiation of adaptive immune response

20

What is a mast cell?

expulsion of parasites through release of granules (esp histamine)

21

What is a macrophage?

phagocytosis and killing of microorganisms - activation of T cells and initiation of immune responses

22

What is a eosinophil?

killing of antibody-coated parasites through release of granule contents

23

Where do monocytes come from?

bone marrow derived (called macrophages when enter tissues)

24

What is a neutrophil?

phagocytosis and killing of microorganisms

25

CD3

mature T cells

26

CD4

T-helper

27

CD8

T-cytotoxic

28

CD28

recognition of presenting cells

29

CD40

co-stimulatory molecule

30

CD25

IL-2 receptor (high affinity)

31

What is an opsonin? Give an example

something that increases phagocytosis by binding to the antigen - example: complement