Flashcards in Immunology Lecture 13. Deck (17):
What are the signals for an NK cell?
IFN-2, IFN-B, TNF-2, IL12
Where are NK cells made?
What is the default response of an NK cell?
leave the cell alone - activating signals must overcome a threshold
Where are NK cells activated?
locally, as opposed to T cells which are activated in lymph tissue
What are the unique markers for NK cells?
TLR 3 and TLR 8
What molecule helps NK cell recognize self? Is it inhibitory or activating?
CD94:NKG2A complex —> inhibitory
What does CD94:NKG2A complex recognize?
MHC Class I (HLA-E) - *no peptide needed*
What two signals activate NK cells?
2B4-CD48 and NKG2D-MIC
recognizes NK cells (on target cells)
special because it recognizes antibody - only one signal needed to activate the NK cell
Where is the threshold set for activating and NK cell?
CD94 with what is an activating signal?
NKG2L (as opposed to NKG2A which is an inhibitory signal)
How do gamma delta T cells differ from alpha betta T cells?
YD T cells mostly in gut and are abundant in tissues while AB are in blood
What do YD T cells recognize?
What is the main function of YD T cells?