Immunology Lecture 13. Flashcards Preview

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Flashcards in Immunology Lecture 13. Deck (17):
1

What are the signals for an NK cell?

IFN-2, IFN-B, TNF-2, IL12

2

Where are NK cells made?

bone marrow

3

What is the default response of an NK cell?

leave the cell alone - activating signals must overcome a threshold

4

Where are NK cells activated?

locally, as opposed to T cells which are activated in lymph tissue

5

What are the unique markers for NK cells?

TLR 3 and TLR 8

6

What molecule helps NK cell recognize self? Is it inhibitory or activating?

CD94:NKG2A complex —> inhibitory

7

What does CD94:NKG2A complex recognize?

MHC Class I (HLA-E) - *no peptide needed*

8

IL-8

recruit neutrophils

9

What two signals activate NK cells?

2B4-CD48 and NKG2D-MIC

10

CD48

recognizes NK cells (on target cells)

11

CD16

special because it recognizes antibody - only one signal needed to activate the NK cell

12

Where is the threshold set for activating and NK cell?

bone marrow

13

CD94 with what is an activating signal?

NKG2L (as opposed to NKG2A which is an inhibitory signal)

14

How do gamma delta T cells differ from alpha betta T cells?

YD T cells mostly in gut and are abundant in tissues while AB are in blood

15

What do YD T cells recognize?

IPP

16

What is the main function of YD T cells?

promote inflammation

17

Where are MAIT cells?

mucosa