Infections of the airway Flashcards

(48 cards)

1
Q

Satellitism on blood agar in H influenzae

A

S aureus induced hemolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Vaccine type for Hib

A

PRP conjugate vaccine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Prophylaxis in unvaccinated for Hib

A

Rifampin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Diagnostic tool contraindicated in epiglottitis

A

Throat swab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Possible causes of croup

A

Parainfluenza 1-3
Bordetella pertussis
Influenza
RSV
Adenovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Possible causes of epiglottitis

A

H influenzae
GAS
S aureus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Susceptible age to croup

A

6 mos to 3 yrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Croup presentation in adults

A

Acute laryngitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Enveloped negative sense RNA virus that causes croup

A

Parainfluenza

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Virulence factors of Parainfluenza

A

H&N proteins
F fusion protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Virus causing inflammatory changes in superficial mucus membrane of the larynx, trachea, and bronchi that leads to a loss of cilia, cell damage, and edema

A

Parainfluenza

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Diagnostic test for Parainfluenza

A

Rapid antigen detection test (RADT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

X-ray findings in epiglottitis

A

Thumb sign in throat - epiglottis swelling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

X-ray finding in croup

A

Steeple sign –> visible narrowing of upper airway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Treatment for croup

A

Humidification
Epinephrine
Steroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Paramyxoviridae Morbillivirus

A

Measles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Paramyxoviridae Paramyxoviruses

A

Parainfluenza
Mumps

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Paramyxoviridae Pneumovirus

A

RSV
Metapneumovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Family of enveloped negative sense ssRNA viruses that replicate in cytoplasm

A

Family Paramyxoviridae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Motile, obligate aerobe, gram negative coccobacilli that causes laryngotracheobronchitis

A

Bordetella pertussis

21
Q

Adhesion and attachment virulence factors of Bordetella pertussis

A

Filamentous hemagglutinin
Pertactin
Tracheal cytotoxin

22
Q

Non-attachment virulence factors of Bordetella pertussis

A

Adenylate cyclase toxin
Pertussis toxin
Hemolysin

23
Q

Mechanism of hemolysin virulence factor

A

Induces apoptosis of macrophages and bronchopulmonary cells

24
Q

Mechanism of pertussis toxin

A

ADP ribosylation of Gi protein to impair chemotaxis and increases sensitivity to histamine

25
Mechanism of adenylate cyclase toxin A (CyaA) virulence toxin
Calmodulin dependent activation of cAMP that impairs chemotaxis
26
Duration of classic pertussis
6-10 wks
27
Special media for culture of Bordetella pertussis
Bordet Gengou/Regan Lowe
28
Treatment of choice for Bordetella pertussis
Erythromycin/macrolide
29
Pertussis complication in infants
Conjunctival injection
30
Complications of pertussis in adolescents and adults
Syncope Weight loss Sleep disturbance Incontinence Rib fractures Pneumonia
31
Orthomyxovirus that causes laryngotracheobronchitis Enveloped, negative sense ssRNA with a segmented genome
Influenza
32
Virulence factors of Influenza virus
H&N Matrix protein
33
Point mutations in genes coding for H and N that alters viral antigenicity
Antigenic drift
34
Reassortment of genome segments of different human and animal strains of influenza with random mixing during co-infection
Antigenic shift
35
CXR findings in influenza
Bilateral diffuse interstitial infiltrates
36
Extrapulmonary complications of influenza virus
Reye's syndrome Myositis Myocarditis Pericarditis
37
Neuraminidase inhibitors used for influenza and there method of administration
Oseltamivir (PO) Zanamivir (inhalation)
38
Treatment options for influenza, type A only
Amantadine Rimantadine
39
Treatment options for influenza, types A & B
Neuraminidase inhibitors --> Oseltamivir and Zanamivir
40
Mechanism of Amantadine and Rimantidine
Neutralize acidic pH within viral endosome
41
Types of flu vaccine
Killed vaccine --> injection Live attenuated vaccine --> nasal spray
42
Morphology of RSV
Enveloped, negative sense ssRNA that replicates in cytoplasm
43
Virulence factors of RSV
G protein and F protein
44
Possible viral causes of bronchiolitis
RSV Metapneumovirus Adenovirus Parainfluenza virus
45
What should be suspected in an infant who presents with high fever, rhinitis, fussing, crying, refusing feeding, and no cough?
RSV
46
Inflammation of terminal bronchioles with necrosis and sloughing of epithelium lining bronchioles
Bronchiolitis
47
Treatments for RSV
Ribavirin RSV-IGIV Palivizumab
48
Viral causes of acute bronchitis
RSV Influenza Parainfluenza Adenovirus Rhinovirus Coxsackie ECHO