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Respiratory II > Treatment of restrictive lung diseases > Flashcards

Treatment of restrictive lung diseases Flashcards

1
Q

Drug for idiopathic pulmonary fibrosis that inhibits RTKs (VEGFR, FGFR, and PDGFR)

A

Nintedanib (Ofev)

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2
Q

Result of RTK inhibition

A

Decreased angiogenesis, proliferation, migration, invasion, and permeability

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3
Q

Drug for idiopathic pulmonary fibrosis that inhibits TGF-beta

A

Pirfenidone (Esbriet)

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4
Q

Immunosuppressants used to reduce inflammation in idiopathic pulmonary fibrosis

A

Azathioprine
Cyclophosphamide
Mycophenolate mofetil

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5
Q

Mechanism of azathioprine

A

Inhibits purine synthesis

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6
Q

Mechanism of cyclophosphamide

A

Alkylating agent of DNA causing cross-linking

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7
Q

Mechanism of mycophenolate mofetil

A

IMDH inhibitor

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Respiratory II (17 decks)

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