Infections of the Sensory System Flashcards

(53 cards)

1
Q

what is innate immunity

A

non-specific diseases

1st line
skin
mucous membranes
secretions

2nd line
phagocytic leukocytes
antimicrobial proteins
inflammatory response
fever

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2
Q

what is adaptive immunity

A

third line

lymphocytes
antibodies
memory cells

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3
Q

what are ocular defence mechanisms

A

innate
-eyelids- sweep away dirt, small microbes
-tears, mucin
-ocular epithelium
-ocular bacterial flora
-antibacterial factors
-macrophages and NK cells
-BONY ORBIT

oil later
water layer
mucin layer
corneal epithelium-non keratanised with goblet cells for lubrication of eye

adaptive defence
-eye associated lymphoid tissue
-langerhan’s cells
-immunoglobins
-t lymphocytes
-b-lymphocytes

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4
Q

what makes up the bony orbit

A

frontal, sphenoid, maxillary, zygomatic, palatine, ethmoid, and lacrimal

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5
Q

what are langerhan’s cells

A

sub-population of dendritic cells
catch and report to t and b lymphocytes
sit on cornea and in transplant causes rejection

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6
Q

what is a blow out fracture

A

-high pressure in sinus and blow nose
-trauma

fractured maxillary bone
eyeball fall into maxillary sinus
stress and damage on optic nerve and extraocular eye muscles

lets infection from sinus into orbit

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7
Q

discuss role of lysozome and lactoferrin

A

enzymes found in tears

lysozyme cleaves PEPTIDOGLYCANS (found in bacteria walls)– good with gram positive who has it in their outer wall

lactoferrin binds IRON- STARVES bacteria and fungi blocks viral lipoprotein bonds
-alters the permeability of the lipopolysaccaride later giving access for lysozyme

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8
Q

what is found in the ocular biome

A

staphylococcus
streptococcus
propionbacterium
corynebacterium

collection of commensals
keep immune system prime
competitively inhibit growth of pathogenic organisms
-takes up all resources

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9
Q

what pathogens are found in common viral conjunctivits

A

coronaviruses
rhinoviruese
respiratory syncytial virus
parainfluenza

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10
Q

what are the different kinds of conjunctivitus

A

common viral
adenovirus related
common bacterial
neonatal

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11
Q

symptoms of common viral conjunctivits
how to help

A

sticky
watery
pink
discomfort
slef limiting
rarely cause seious damage
1 eye until spreads

cold compress
artificial tears
sterile water
paracetamol

step in if longer than a week

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12
Q

what are symptoms of adenovirus conjuctivits

A

bilateral
very sticky
red
painful
6-8 weeks
visual blurring– PUNCTUATE KERATITIS
sore throat and cough

same as common viral conjunct for treatment

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13
Q

what are the symptoms for bacterial conjunctivitis
what treatments

A

discharge more yellow than viral
go away with ANTIBIOTICS

-CHLORAMPHENICOL
-FUSIDIC ACID

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14
Q

what can cause bacterial conjunctivitis

A

haemophilus influezae
streptococcus pneumoniae
moraxella

if discharge very xs– may be ghonnorea

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15
Q

what causes neonatal conjunctivits

A

may be normal bacterial/viral/sti from birth canal

0 days
neisseria gonorrhoeae

5 days
chlamydia trachomatis

5 weeks
haemophilus influenza
streptococcus

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16
Q

what is keratitis
what can cause it

A

corneal abrasion
inflammation of cornea

bacterial- staph. aureus, strept. pne, pseudomonas species
viral- HSV, HZO
fungi

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17
Q

what happens in keratitis

A

inflammation seeps through into different corneal layers
causes noxious response which dissolves cornea epithelium and stroma
–ulceration and scarring

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18
Q

what is hypopynum

A

an accumulation of leukocytes in the anterior chamber due to severe intraocular inflammation

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19
Q

how is the cornea weakened

A

more issues if dry-> keratoconjunctivitis sicca DRY EYE DISEASE

tear film deficiencies
eyelid malformation- exposure of cornea
endogenous cause-mechanical abrasion
exogenous cause- TRAUMA (foreign bodies, cat scratches)

if can’t close eye eg. after stroke

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20
Q

how do HSV keratitis occur
what are the symptoms
how do you treat

A

usually direct contact
(like from cold sore)
UNILATERAL

painful
red
watery
photophobic

topical and oral ACICLOVIR

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21
Q

what are the different types of ulcer found in HSV keratitis

A

dendritic ulcer
geographic ulcer

these cause new vessels, loss of sensation, scarring

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22
Q

what is the leading infectious cause of blinding

23
Q

how does trachoma come about
what is the infective cause

A

between close contact from lack of hygiene, sanitisation
flies

eyelids turn in– trachomatous trichiasis
–scarring
which causes permanent blindness
(fixed with corrective surgery)

CHLAMYDIA TRACHOMATIS

24
Q

what is trachomatis trichiasis

A

in turned lash that rubs the cornea
causes recurrent inflammation in conjunctiva

25
what is trachoma eradication trying to do
to clear trachoma from endemic populations Surgery Antibiotics Facial cleanliness Environmental change
26
what is ONCHOCERCIASIS
river blindness 2nd leading causing of infection blindness CENTRAL AFRICA parasitic disease onchocerca larvae carried by black flies worm bites birth larvae which spreads to different tissues like eye and die which causes inflammation
27
what is the treatment for river blindness
IVERMECTIN -yearly for 10-15 years clear from population
28
what is orbital cellulitis signs how it presents
ophthalmological med emergency 2 types- pre and post septal cellulitis post is more dangerous: spread of infection into deeper structures orbital abscess (push eyeball out) meningitis cavernous sinus thrombosis optic nerve damage bacteremia/sepsis pre (just area around eye) signs? swelling red pain proptosis RAPD tenderness photophobia
29
what infections cause orbital cellulitis
haem. influenza staph. a strept. pn neta-haemolytic streptococci
30
31
what is toxoplasmosis retinochoroidits what species causes it
infectious condition retinochoroidal lesions postior uveitis FOG IN HEADLIGHT SIGN WITH ADJACENT PIGMENTENTED RETINAL CHOROIDAL SCARRING toxoplasmosis gondii (cat litter) -spontaneous miscarriage -blindness -enchephalitis
32
what is the treatment for toxoplasmosis
oral pyrimethamine sulfadiazine corticosteroids
33
what are some ocular manifestations of patients with HIV/AIDS
retinochoroiditis toxoplasma endophthalmitis HIV reproduces in CD4+ t cells can tell what they might be susceptible by their cell count 250/uL- toxoplasmosis 100/uL- CMV
34
what is cytomegalovirus retinitis CMV what is treatment
cotton wool on retina antiviral ganciclovir
35
what is endophthalmitis treatment
develops after intra-ocular operation trauma with inoculation of foreign body complication of systemic infection intra-ocular and systemic antibiotics virectomy
36
what is otitis externa
epithelium of the ear can be affected by comon skin conditions eg. eczema, psoriasis pain ear ache itch discharge swimmers ear- gets moist for bacteria to grow in cottage cheese discharge, can be blood stained conduction deafness ear drops
37
what is innate immune system for upper resp. tract
hair follicles ciliated cells
38
what are common microorganisms for otitis externa
pseudomonas aeeruginosa staph aure. less common candida albicans aspergillus niger
39
what is otitis media what are pathogen
middle ear most common in infants and small children- flatter eustachian tubes 50% viral in origin mainly RSV also s. pneu, and h. inflenzae young: red ears, fever, crying, poor feeding, restlessness, hearing difficulties, delayed learning development glue ear- fluid in middle ear bulging ear drum and dilated vessels chronic suppurative otitis media
40
what is mastoiditis
a severe complication of otitis media spread of infection from middle ear to mastoid air cells via the mastoid antrum mastoid process inflammation redness tenderness pain behind the ear pushed forward pinna fever fatigue if unwell IV antibiotics
41
what is sinusitis
pathogen invasion of the air spaces associated with URT mucosal swelling prevents muco-ciliary clearance of infection exacerbated by local accumulation of inflammatory bacterial products nasal blockage discharge with facial pain/pressure/loss of smell self limiting increase in symptoms after day 5 of urt infection -double sickening
42
what are causative agents of comomon cold and symptoms
40%rhino 30% coronaviruses coxsackie virus a echovirus parainfluenza virus tired, pyrexia, malaise, sore nose, pharynx. nasal discharge, sneezing
43
what is pharyngitis when should you worry
Pharyngitis is often is associated with pharyngeal exudate and cervical lymphadenopathy * Sore throat, reduced oral/fluid intake, fatigue, lethargy, fever, Headache, nausea, vomiting. * Management: Self-limiting for most, antibiotics need to be considered for some. worry if taking DMARDS, carbimazole, HIV, chemo
44
what causes pharyngitis
Viruses * Cytomegalovirus (CMV) * Epstein-Barr virus (EBV) * Herpes simplex virus type I (HSV-1) * Rhinovirus * Coronavirus * Adenovirus * Bacteria * Streptococcus pyogenes * Haemophilus influenzae * Corynebacterium diphtheriae
45
discuss CMV
Cytomegalovirus (CMV) * Transmission in body secretions and organ transplants * Usually asymptomatic or mild in healthy adults * CMV causes cold-like symptoms, such as a sore throat, fever, fatigue and swollen glands. * Symptoms last for only a few short weeks and is not worrying for healthy children or adults. * Virus can reactivate and cause disease when cellmediated immunity is compromised * Treatment with ganciclovir, foscarnet, cidofovir
46
what is tonsilitis
Inflammation of the tonsils – typically palatine. Can be viral or bacterial. Therefore – may or may not need antibiotics. * Symptoms: Dysphagia, odynophagia, cervical lymphadenopathy, fever * 90% of cases will resolve in 7 days without treatment
47
what is fever pain scoring
* A score of 0-1 is associated with 13-18% isolation of streptococcus (close to background carriage rates). * No antibiotics recommended. * A score of 2 is associated with 30-35% isolation of streptococcus. * Delayed antibiotic may be appropriate. * A score of 3 is associated with 39-48% isolation of streptococcus. * Delayed antibiotic may be appropriate. * A score of 4 or more is associated with 62- 65% isolation of streptococcus. * Consider antibiotics if symptoms are severe or a short delayed prescribing strategy may be appropriate (48 hours).
48
what are some complications of streptococcus pyogenes
complications * Scarlet Fever * Caused by erythrogenic toxin from S. pyogenes * Peritonsillar abscess (“quinsy”) * Otitis media / sinusitis * Rheumatic heart disease * Glomerulonephritis acute Group A streptococcal (GAS): * 5 to 15 years old * more common in the winter * High Fever PAIN or CENTOR score * A scarlatiniform rash may be present, especially in children. * Significant complications if not treated Treatment: * Able to swallow Benzylpenicillin IV * Unable to swallow Penicillin V * Paracetamol, Ibuprofen, IV Fluids
49
what is quinsy
* Collection of pus between the tonsillar capsule and superior constrictor muscle. * Complication of untreated bacterial pharyngitis / tonsillitis * Symptoms: Fever, pain, trismus, general malaise * Signs: Hot-potato voice, unilateral swelling, deviation of uvula * Management: Same day hospital admission to ENT. * Needle aspiration / drainage, IV antibiotics (Penicillin based) and IV Steroids, analgesia and IV Fluids until oral route available. * Complications: Retropharyngeal or deep neck space infection in fascial planes of the neck, HOT POTATO VOICE
50
what is glandular fever
Replicates in B lymphocytes * Clinical features: * Fever * Headache * Malaise * Sore throat * Anorexia * Palatal petechiae * Cervical lymphadenopathy * Splenomegaly * Mild hepatitis Diagnosis: EBV Serology, FBC and LFTs EBV IgM – Acute 4-6 weeks EBV IgG – Lifelong (Indicative of past infection)
51
what is the mumps virus
parotitis Clinical features: * Fever, Malaise, Headache * Anorexia, Trismus, joint pain * Severe pain and swelling of parotid gland(s) * Treatment is supportive / symptomatic * 88% resistance with full vaccination
52
what is acute epiglottitis
HAEMOPHILUS INFLUENZA * Present in nasopharynx of 75% healthy people * 88% reduction in cases since vaccine in 1992 * Clinical features: * High fever / Bacteraemia * Massive oedema of the epiglottis - tripod position * Severe airflow obstruction – Stridor, Dysponoea Most often seen in young children 2 to 6 years of age MEDICAL EMERGENCY needing 999 ambulance to hospital for intubation and IV antibiotics. Do Not examine a child with suspected epiglottitis without an anaesthetist.
53
what is diagnosis and treatment for diptheria
diagnosis: * Made on clinical grounds as therapy is usually urgently required * Treatment: * Prompt anti -toxin therapy administered intramuscularly * Concurrent antibiotics (penicillin or erythromycin) * Strict isolation and contact tracing