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Flashcards in Infectious Particles Deck (18)
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1

What are viruses?

obligate intracellular parasites, can only replicate inside host cells

2

What are host cells?

include all groups of cellular organisms

3

What are virons?

viruses outside the host cell, inert infectious particles

4

each type of virus is essentially a piece of ___ enclosed in a ___, only one type of ___ is found in the iron of a given virus

nucleic acid/capsid/nucleic acid

5

___ viruses have 3 PRO, ___ viruses have >100 PRO

simple/complex

6

Hosts supply the ___ for viruses, as well as the ___ and ___ to reproduce

building blocks/machinery/energy

7

What are the parts that make up a viron?

- envelope: lipid containing layer with embedded PRO
- capsid: PRO coat around n.a.
- nucleic acid
- capsomeres: PRO subunit that makes up to capsid

8

What does the nucleocapsid refer to?

the capris and the nucleic acid

9

PRO in the envelope are ___ and encoded on the ___

virus-specific/viral genome

10

Shape is determined by:

the nature of capsomeres

11

Describe helical viruses

cylindrical, typical of plant viruses, spiral RNA core attached to identical capsomeres

12

Describe polyhedral viruses

several possible shapes, most common is the icosehedron (20 triangular faces), some contain more faces by having clusters of polyhedral on the surface (ex. HPV)

13

complex viruses are composed of ___ parts, the most complex are ___ which are made to infect ___

several/phages/bacteria

14

What are viroids?

closed single strand RNA circles, replication is dependant on host machinery, disease is caused when the viroid overtakes the host

15

What are some examples of viroid diseases?

cadang cadang, potato spindle tuber)

16

Where are prions?

only one PRO, cause neurological disease

17

What are some examples of prion diseases?

mad cow, scrapie, CJD, VCJD, kuru

18

___ prion PRO (PrPsc) induces misfolding of ___ PRO so prion does not replicate it, it includes an accumulation of misfolded PrPsc which ___ the cell, PrPsc is primarily found in ___

midfolded/PrPc/kills/neurons