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Pathology Definitions > Inflammation and Repair > Flashcards

Inflammation and Repair Flashcards

1
Q

The process of reaction of vascularized living tissue to injury is called?

A

Inflammation

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2
Q

Process by which lost or necrotic cells are replaced by vital cells

A

Repair

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3
Q

Replacement by cells of same type

A

Regeneration

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4
Q

Replacement by connective tissue

A

Scarring/fibrosis

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5
Q

Protein rich fluid, inflammatory cells, cellular products, and cell debris accumulation at the site of an inflammatory reaction

A

Exudates

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6
Q

Cell migration along a concentration gradient of inflammatory mediator

A

Chemotaxis

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7
Q

Random migration stimulated by a chemical mediator

A

Chemokinesis

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8
Q

The protein rich fluid and inflammatory cells that accumulate in extracellular spaces as a result of an inflammatory reaction

A

Exudate

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9
Q

Refers to elimination of the inflammatory stimulus and senescence and removal of inflammatory cells after active inflammation

A

Resolution

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10
Q

Inflammation resulting from injurious stimuli that are persistent, often for weeks or months, leading to a predominantly proliferative, rather than exudative, reaction

A

Chronic inflammation

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11
Q

An inflammatory process dominated by macrophages

A

Granulomatous inflammation

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12
Q

A compact and organized collection of mononuclear inflammatory cells (macrophages, lymphocytes, and plasma cells) dominated by macrophages

A

Granuloma

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13
Q

Organized and compact aggregate of MOs and/or epithelial cells with other inflammatory cells such as lymphocytes and plasma cells

A

Simple granuloma

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14
Q

Granuloma with central necrosis and possibly calcification

A

Complex granuloma

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15
Q

Process resulting in an increase of collagen in tissue

A

Fibrosis

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16
Q

Highly organized fibrovascular tissue that often replaces necrotic debris and areas where poor regeneration occurs

A

Granulation tissue

17
Q

Cells that continue to multiply throughout life and replenish those lost due to normal turnover

A

Labile cells

18
Q

Cells with latent capacity to regenerate

A

Stable cells

19
Q

Cells with no capacity to regenerate additional cells

A

Permanent cells

20
Q

Potent growth factor produced by MOs, stromal fibroblasts, and to a lesser extent by epithelial cells in some tissues that is a potent inducer of epithelial proliferation and repair

A

Epidermal growth factor

21
Q

Growth factor produced by MOs, platelets, endothelial cells, smooth ms cells; stimulates smooth ms proliferation and fibrosis

A

Platelet derived growth factor

22
Q

Produced by MOs and other cells; potent inducer of endothelial cell proliferate and angiogenesis

A

Basic fibroblast growth factor

23
Q

Produced by MOs and other cells including smooth ms cells, fibroblasts, platelets, and some epithelial cells; promotor of fibrosis and inhibits epithelial regeneration

A

Transforming growth factor beta

24
Q

Highly potent angiogenesis factor produced by MOs, smooth ms cells, and epithelial cells in tissues; also produced by many malignant tumors and assists in neoplasm angiogenesis

A

Vascular endothelial growth factor

25
Q

Produced on MOs, monocytes, and fibroblasts with wide range of biological properties

A

Tumor necrosis factor alpha

26
Q

Replacement of fibrin and necrotic debris by granulation tissue

A

Organization

27
Q

Tough sheet of fibrin

A

Pseudomembrane

28
Q

Detachable fibrinous exudate

A

Croupous

29
Q

In contrast to croupous, the fibrinous exudate is firmly attached to the underlying surface and cannot be removed without tearing off a superficial layer of bleeding surface

A

Diptheritic

30
Q

Retains the shape of the structure from which it was molded

A

Fibrinous cast

31
Q

Pus in a confined area

A

Abscess

32
Q

Pus spread thinly throughout (or diffusely) without being walled off (subcutaneously and along fascial plane)

A

Phlegmon (cellulitis)

33
Q

Accumulation of pus in a body cavity

A

Empyema

34
Q

Abscess consists of inspissated pus surrounded by a thick fibrous capsule

A

Cold abscess/ chronic abscess

35
Q

Made or having become thickened in consistency

A

Inspissated

Pathology Definitions (7 decks)

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