Inflammatory Bowel Disease Flashcards
(18 cards)
What does IBD involve?
Recurrent episodes of inflammation in the GI tract.
What are the two main types of IBD?
Ulcerative colitis and Crohn’s disease.
What are the periods associated with IBD?
Periods of exacerbation and remission.
List general clinical features of IBD.
- Diarrhoea
- Abdominal pain
- Rectal bleeding
- Fatigue
- Weight loss
What does NESTTS stand for in Crohn’s disease?
- N - no blood or mucus
- E - entire GI tract
- S - ‘skip’ lesions
- T - terminal ileum most affected
- T - transmural thickness
- S - smoking risk factor
What are additional clinical features of Crohn’s disease?
- Strictures
- Fistulas
- Mouth ulcers
What does CLOSEUP stand for in ulcerative colitis?
- C - continuous inflammation
- L - limited to colon and rectum
- O - only mucosa
- S - smoking protective
- E - excrete blood and mucus
- U - use aminosalicylates
- P - primary sclerosing cholangitis
List associated conditions with IBD.
- Erythema nodosum
- Pyoderma gangrenosum
- Enteropathic arthritis
- Primary sclerosing cholangitis (UC)
- Red eye conditions (episcleritis, scleritis, anterior uveitis)
What is the specificity of faecal calprotectin for IBD?
90% specific.
Name three types of investigations for IBD.
- Faecal calprotectin
- Colonoscopy
- Imaging (USS, CT, MRI)
What are the two aims of IBD management?
- Inducing remission (during exacerbation)
- Maintaining remission
What is the first line management for mild-moderate ulcerative colitis?
Aminosalicylate (e.g. mesalazine).
What is the second line management for mild-moderate ulcerative colitis?
Corticosteroids (e.g. prednisolone).
What is the management for severe ulcerative colitis?
IV steroids (e.g. IV hydrocortisone).
List other management options for ulcerative colitis.
- IV ciclosporin
- Infliximab
- Surgery (panproctocolectomy, ileostomy, J-pouch)
What is the first line management for inducing remission in Crohn’s disease?
Steroids (e.g. pred or hydrocortisone).
What are some other medications for inducing remission in Crohn’s disease?
- Enteral nutrition
- Azathioprine
- Methotrexate
- Infliximab
- Adalimumab
What is the maintenance therapy for Crohn’s disease?
- Azathioprine
- Mercaptopurine
