Inflammatory Myopathiess

Question 1

what does myositis refer to

Answer 1

striated muscle inflammation

Question 2

what 2 conditions are due to myositis

Answer 2

polymyositis and dermatomyositis

Question 3

what causes polymyositis

Answer 3

autoimmune

Question 4

what causes dermatomyositis

Answer 4

autoimmune or paraneoplasitc

Question 5

age and gender affected by polymyositis

Answer 5

female age 40 - 50

Question 6

age and gender affected by dermatomyositis

Answer 6

female age 40 - 50

Question 7

what conditions are associated with dermatomyositis and polymyositis

Answer 7

Raynaud’s, interstitial lung disease, malignancy

Question 8

what component of the immune system is dysfunctioning in polymyositis

Answer 8

CD8

Question 9

what component of the immune system is dysfunctioning in dermatomyositis

Answer 9

CD4

Question 10

how does myositis present

Answer 10

myalgia, arthralgia, dysphagia, dysphonia, fever, myocarditis

Question 11

how does the presentation of polymyositis and dermatomyositis differ

Answer 11

dermatomyositis also has cutaneous presentation

Question 12

how does dermatomyositis affect the skin

Answer 12

Gottron’s papule
heliotrope (purple) oedematous rash around eyes
Shawl sign

Question 13

what is shawl sign

Answer 13

erythematous rash on upper back

Question 14

where are gottron’s papules found

Answer 14

around MCP and PIP joints

Question 15

autoantibodies in polymyositis and dermatomyositis

Answer 15

ANA
anti-Jo-1
anti-SRP
anti-RNP

Question 16

blood tests for dermatomyositis and polymyositis

Answer 16

autoantibodies, CK, ALT, AST

Question 17

imaging for dermatomyositis and polymyositis

Answer 17

MRI

Question 18

additional tests (not imaging or blood tests) for dermatomyositis and polymyositis

Answer 18

electromyogram

muscle biopsy

Question 19

management of polymyositis and dermatomyositis

Answer 19

prednisolone +- DMARD/biologic

Question 20

which muscles are mainly affected by polymyositis and dermatomyositis

Answer 20

proximal muscles

Question 21

which muscles are mainly affected by inclusion body myositis

Answer 21

distal muscles e.g. wrist, finger

Question 22

dermatomyositis and polymyositis are progressive. true or false

Answer 22

true

Question 23

dermatomyositis and polymyositis are symmetrical. true or false

Answer 23

true

Question 24

inclusion body myositis is symmetrical. true or false

Answer 24

false; asmmetrical

Question 25

age and gender affected by inclusion body myositis

Answer 25

men over 50

Question 26

age affected by polymyalgia rheumatica

Answer 26

over 50

Question 27

condition associated with polymyalgia rheumatica

Answer 27

giant cell arteritis

Question 28

what areas of the body are affected by polymyalgia rheumatica

Answer 28

shoulder and hip

Question 29

is polymyalgia rheumatica rapid or insidious onset

Answer 29

rapid

Question 30

is polymyalgia rheumatica symmetric

Answer 30

yes

Question 31

does polymyalgia cause weak or stiff muscles? or bothh

Answer 31

only stiff

Question 32

systemic presentation of polymyalgia rheumatica

Answer 32

fatigue and weight loss

Question 33

blood tests for polymyalgia rheumatica

Answer 33

ESR, PV, CRP (all raised)

Question 34

how is polymyalgia rheumatica diagnosed

Answer 34

by exclusion

Question 35

management of polymyalgia rheumatica

Answer 35

15mg prednisolone

Question 36

age and gender most affected by fibromyalgia

Answer 36

young/middle age women

Question 37

conditions linked to fibromyalgia

Answer 37

depression, IBS, SLE, RA

Question 38

presentation of fibromyalgia

Answer 38

sleep disturbance, memory problems, diffuse pain, night sweats

Question 39

what is seen on examination in fibromyalgia

Answer 39

tender

Question 40

how is fibromylagia diagnosed

Answer 40

by exclusion

Question 41

how long must symptoms have been present for a fibromyalgia diagnosis

Answer 41

3 months

Question 42

management of fibromyalgia

Answer 42

CBT, anti-depressant, analgesia

Question 43

blood tests for fibromyalgia

Answer 43

normal inflam markers (PV, CRP, ESR)