Inflammatory/ neoplasia Bone dz

Question 1

Osteitis

Answer 1

Inflammation of bone

-general term

Question 2

Periostitis

Answer 2

Inflammation of periosteum

Question 3

Osteomyelitis

Answer 3

Inflammation of medullary cavity

-most common inflammatory condition

Question 4

Bone sequestrum

Answer 4

• Fragment of dead bone
• surrounded by inflammatory cells and exudate

(chronicity –> involucrum)

Question 5

Involucrum

Answer 5

Sequestrum surrounded by DENSE RING of reactive bone

Question 6

Infectious Osteomyelitis

Answer 6

• most common in neonatal farm animals
• hematogenous distribution

-Fungi are more common in domestic animals

Question 7

Viral osteomyelitis

-Viruses w/ true inflammation

Answer 7

• Hog cholera
• Canine hepatits virus

–> endothelial damage –> metaphyseal hemorrhage

Question 8

Viral osteomyelitis

-Virus w/o true infection

Answer 8

• Distemper virus
  
  • Osteoclast infection –> growth retardation lattice (disrupt growth plate modeling)
• FeLV
  
  • infection/necrosis of hematopoietic cells –> myelosclerosis

Question 9

Metaphyseal Osteopathy

Answer 9

Osteomyelitis of trabecular bone w/ periosteal bone formation

• Multiple swollen joints & fever
• Young, Lg breed dogs

Oblasts die & matrix reduces –> trabeculae collapse –> (Bilateral) parallel fracture at growth plate

Question 10

Rads of Metaphyseal osteopathy

Answer 10

Alternatig dense and lucent areas parallel to physis

BILATERAL

Question 11

Aseptic necrosis of bone

Answer 11

• Retain growth plate

- lack mineralization

Question 12

Legg Calve Perthes Dz

Answer 12

Asceptic necrosis of femoral head –> collapse of articular cartilage
–Miniature dogs

Question 13

Clincal signs of Bone neoplasias

Answer 13

• lameness
• pain
• hypercalcemia
• increase ALP
• fractures

Question 14

Tumors w/ abundant fibrous stroma –>

Answer 14

NEW bone formation

Tumors w/ little stroma (lymphoma) –> no bone/lysis

Question 15

Hypertrophic osteopathy

Answer 15

Progressive, bilateral periosteal bone formation of diaphysis of distal limbs

Always have some kind of space occupying mass

Question 16

Osteochondromas

Answer 16

*NOT a neoplasm
Multiple masses adj to physes of long bones & ribs
*possible malignant transformation

-Cat –more common in adults and in flat bones

Question 17

Fibrous dysplasia

Answer 17

Multifocal lytic intraosseous lesions
-young animals

• Pre-existing bone exchanged for well-diff fibrous tissue & woven bone
• *no Oblast

Question 18

Bony cysts

Answer 18

Sequelae of:

• osteochondrosis
• degenerative joint dz
• ischemia
• malformation

Question 19

Name 6 Primary neoplasms of bone

Answer 19

1. Ossifying fibromas
2. Chondromas
3. Chondrosarcomas
4. Osteomas
5. Osteosarcomas
6. Multilobular tumor of bone

Question 20

Ossifying fibroma

Answer 20

• Benign
• maxilla/mandible
• Young HORSE & CATTLE

Fibrous tissue (fibroblasts) w/ woven bone and osteoblasts

Question 21

Chondroma/sarcoma

Answer 21

Tumors of hyaline cartilage

• NO osteoid
• *Mets to LUNGS
• *Bypass LN

Question 22

Osteoma/sarcoma

Answer 22

Central = in medullary cavity
Perio-steal = from periosteum onto medullary 
Paro-steal = from periosteum into soft tissue

• Rads = common to see starburst

Question 23

MultiLobular Tumor of Bone

Answer 23

• Single Nodular Immobile mass
  
  • partially mineralized
  • separated by CT
• Flat bones (skull, hard palate)
• DOGS