Flashcards in Innate Immunity Deck (10):
What are the 3 phases of immunity?
+ early induced
What are the three activation pathways of the complementary system?
What is the trigger for the classical pathway?
antibody binds to specific antigen on pathogen surface
What is the trigger for the lectin pathway?
mannose-binding protein binds to pathogen surface
What is the trigger for the alternative pathway?
pathogen surface creates local environment conducive to complement activation
What is the output for the classical pathway?
recruitment of inflammatory cells
What is the output for the lectin pathway?
opsonisation of pathogens, facilitating uptake and killing by phagocytic cells
What is the output for the alternative pathway?
lysis and death of pathogens
What is the role of complement protein, C3b?
opsonin - promotes phagocytosis