Innate Immunity Flashcards Preview

MD2002 > Innate Immunity > Flashcards

Flashcards in Innate Immunity Deck (10):
1

What are the 3 phases of immunity?

+ innate
+ early induced
+ adaptive

2

What are the three activation pathways of the complementary system?

+ classical
+ lectin
+ alternative

3

What is the trigger for the classical pathway?

antibody binds to specific antigen on pathogen surface

4

What is the trigger for the lectin pathway?

mannose-binding protein binds to pathogen surface

5

What is the trigger for the alternative pathway?

pathogen surface creates local environment conducive to complement activation

6

What is the output for the classical pathway?

recruitment of inflammatory cells

7

What is the output for the lectin pathway?

opsonisation of pathogens, facilitating uptake and killing by phagocytic cells

8

What is the output for the alternative pathway?

lysis and death of pathogens

9

What is the role of complement protein, C3b?

opsonin - promotes phagocytosis

10

What is the role of the complement protein, C3a?

peptide mediator for inflammation

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