Intravenous anesthetics Flashcards Preview

Cology 2 Exam 1 > Intravenous anesthetics > Flashcards

Flashcards in Intravenous anesthetics Deck (16):
1

Why are IV anesthetics the most widely used anesthetics for adults?

High lipophilicity and high perfusion into brain and spinal cord

Very rapid onset and short duration after a single bolus dose

2

What's a downside to IV anesthetics?

They accumulate in fatty tissues leading to prolonged recovery especially after multiple doses or infusion

3

Termination of anesthetic effect is not due to metabolism. What is it due to?

Redistribution out of the CNS.

IV anesthetics quickly go into the brain and spinal cord, they slowly leave and enter the blood then the tissues.

Anesthesia goes away when they leave the CNS.

4

Elderly require _____ doses and children require ____ doses of IV anesthetics

Elderly require lower doses, children require higher doses

5

How long does thiopental take to cause unconsciousness?

20 seconds (high lipid solubility)

6

How strong is thiopental's analgesic effect?

It has no analgesic effect

7

How long is thiopental's duration?

5-10 minutes (quickly diffuses from the brain)

8

How is thiopental metabolized?

Nearly completely by the liver

9

How long is thiopental's half-life?

Very long, it accumulates in fat and muscle

10

What effect does thiopental have on CV and respiratory?

Reduces BP and CO
Depresses respiratory center and blunts response to CO2 and hypoxia
Decreases cerebral metabolic rate, CBF, and ICP
Desirable for patients with cerebral edema, protects against ischemia

11

What is the most widely used IV anesthetic in the US?

Propofol

12

How long does propofol take to cause unconsciousness?

20 seconds

13

How long is propofol's duration?

5-10 minutes (high clearance)

14

How fast is propofol metabolized?

10x faster than thiopental
Little accumulation too

15

Which IV anesthetic has anti-emetic properties as well?

Propofol

16

What are side effects of propofol?

Hypotension, pain at site of injection