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Flashcards in Quiz 2 Deck (15):
1

What is the effect of the following drugs on the activity of glutamate receptors (don’t worry about subtype)? (1 pt each)

2. Ethanol Increase / decrease / no effect

3. Pentobarbital Increase / decrease / no effect

Decrease
Decrease

2

What is the effect of the following drugs on the activity of GABA-A receptors (don’t worry about subtype)? (1 pt each)

6. Phenobarbital Increase / decrease / no effect

7. Ethanol Increase / decrease / no effect

Increase
Increase

3

10. Which GABA-A receptor subunit is necessary for the sedative actions of phenobarbital? (1 pt)
Alpha / gamma-2 / delta

Alpha

4

What is the effect of the following drugs on the activity of GABA-A receptors (don’t worry about subtype)? (1 pt each)

1. gamma-hydroxy-butyrate Increase / decrease / no effect

2. Ethanol Increase / decrease / no effect

3. Thiopental Increase / decrease / no effect

No effect
Increase
Increase

5

3A) Pentobarbital increases the activity of GABA-A receptors. (1 pt) True / False

True

6

4A) Ethanol increases the activity of GABA-A receptors. (1 pt) True / False

True

7

7B) Ethanol decreases the activity of glutamate receptors? (1 pt) True / False

True

8

8B) Pentobarbital decreases the activity of glutamate receptors? (1 pt) True / False

True

9

9B) Alcohol dehydrogenase activity follows Zero / First order kinetics while acetaldehyde

dehydrogenase activity follows Zero / First order kinetics. (2 pts)

Zero
First

10

Drinking ethanol before taking a dose of theophylline increases / decreases the

metabolism of theophylline. On the other hand, theophylline metabolism is

increased / decreased in alcoholic patients. (2 pts)

Decreases
Increased

11

Which of the following drugs increases the activity of GABA-A receptors? (answer yes or no, 1 pt each)

3. Buspirone Yes No

4. Ethanol Yes No

No
Yes

12


Which of the following drugs decreases the activity of glutamate receptors? (answer yes or no, 1 pt each)
(1 pt each)

7. Ethanol Yes or No

8. Buspirone Yes or No

Yes
No

13

The following drugs exhibit pharmacokinetic tolerance with repeated daily use. (1 pt each)

6. Ethanol True / False

True

14

8. Ethanol use acutely (increases, decreases) the metabolism of drugs by CYP2E1, but in

an alcoholic, metabolism of drugs by this enzyme is (increased, decreased). (2 pts)

Decreases
Increased

15

At what doses of Barbituates could we use the following to block barbituate action?

Bicuculline
Picrotoxin

Bicuculline - low doses only (barbs can open GABA channels themselves at high doses, so this antagonist wouldn't work)
Picrotoxin - high doses only (able to get in channel to impair flow)