Intro to Innate Immunity Flashcards Preview

HDM Midterm - Brett > Intro to Innate Immunity > Flashcards

Flashcards in Intro to Innate Immunity Deck (32):
1

__________ are also known as suicide enzymes

Granzymes

2

What cell type creates the granzyme?

NK

3

If the NK doesn’t receive the inhibitory signal, ______________, then it will commence cell death

MHC 1

4

NK contain what 2 CD

16, 56

5

NK primarily function in __________ infections

Intracellular

6

Macrophages are activated by ______ and then they secrete __________ which activate NK cells

IFN-gamma, IL12

7

Type 1 interferons directly inhibit ____________________________

Viral replication

8

IFN-a is produced by __________ while IFN-b is produced by ___________. These make up Type ____ interferons

Leukocytes, firbroblasts, 1

9

Type I interferons specifically inhibit viral protein synthesis

False, they inhibit all protein synthesis

10

Chronic granulomatous disease is due to a deficiency in what enzyme

NADPH oxidase, this doesn’t allow ROS to be produced

11

What type of infections are those with chronic granulomatous disease most affected by?

Catalase positive cells are not broken down (staphylococcus, klebsiella, serratia, aspergillus)

12

What is the delayed or failed separation of umbilical cord called?

Omphalitis

13

CGD shows what symptoms

Chronic inflammation such as (gingivitis, enlarged lymph nodes, tumor-like granuloma masses)

14

What is chediak-higashi syndrome?

Autsomal recessive, cytoskeletal defect that doesn’t allow the phagosome and lysosome to fuse

15

Opsonization enhances ____________ up to 4000 fold

Phagocytosis

16

___________ receptors are on human cells that recognize different microbial products

Toll-like

17

_______________________ or PAMPs are generalized patterns that are recognized by immune cells and are not specific to any pathogen

Pathogen associated molecular patterns

18

__________ are released by stressed cells undergoing necrosis

DAMPs

19

_______________ are the professional APCs and serve as a bridge between innate and adaptive immunity

Dendritic cells

20

Dendritic cells express high levels of class ___________ and __________.

2, CD80

21

_________ become __________ when they enter circulation

Monocytes, macrophages

22

CD14 binds to __________ in Gram negative bacteria

LPS

23

Monocytes express _________ as a cell surface marker

CD14

24

Monocytes respond __________ than neutrophils and have a ________ lifetime

Slower, longer

25

Neutrophils serve one purpose: professional _____________

Killers

26

________ make up the majority of the pus

Neutrophils

27

Neutrophils make up _______________ of WBC

A majority

28

The first thing at the site of inflammation is ______________

Neutrophil

29

Neutrophils express _______ and _______

Cd15, cd16b

30

____________ macrophages induced by innate immunity while ___________ macrophages are induced by ________ and ________

Classical, alternative, IL4, IL13

31

TLR4 recognizes what?

Gram negative (LPS)

32

TLR2 recognizes what?

Gram-positive (lipotechoic acid)