Flashcards in Intro to Innate Immunity Deck (32):
__________ are also known as suicide enzymes
What cell type creates the granzyme?
If the NK doesn’t receive the inhibitory signal, ______________, then it will commence cell death
NK contain what 2 CD
NK primarily function in __________ infections
Macrophages are activated by ______ and then they secrete __________ which activate NK cells
Type 1 interferons directly inhibit ____________________________
IFN-a is produced by __________ while IFN-b is produced by ___________. These make up Type ____ interferons
Leukocytes, firbroblasts, 1
Type I interferons specifically inhibit viral protein synthesis
False, they inhibit all protein synthesis
Chronic granulomatous disease is due to a deficiency in what enzyme
NADPH oxidase, this doesn’t allow ROS to be produced
What type of infections are those with chronic granulomatous disease most affected by?
Catalase positive cells are not broken down (staphylococcus, klebsiella, serratia, aspergillus)
What is the delayed or failed separation of umbilical cord called?
CGD shows what symptoms
Chronic inflammation such as (gingivitis, enlarged lymph nodes, tumor-like granuloma masses)
What is chediak-higashi syndrome?
Autsomal recessive, cytoskeletal defect that doesn’t allow the phagosome and lysosome to fuse
Opsonization enhances ____________ up to 4000 fold
___________ receptors are on human cells that recognize different microbial products
_______________________ or PAMPs are generalized patterns that are recognized by immune cells and are not specific to any pathogen
Pathogen associated molecular patterns
__________ are released by stressed cells undergoing necrosis
_______________ are the professional APCs and serve as a bridge between innate and adaptive immunity
Dendritic cells express high levels of class ___________ and __________.
_________ become __________ when they enter circulation
CD14 binds to __________ in Gram negative bacteria
Monocytes express _________ as a cell surface marker
Monocytes respond __________ than neutrophils and have a ________ lifetime
Neutrophils serve one purpose: professional _____________
________ make up the majority of the pus
Neutrophils make up _______________ of WBC
The first thing at the site of inflammation is ______________
Neutrophils express _______ and _______
____________ macrophages induced by innate immunity while ___________ macrophages are induced by ________ and ________
Classical, alternative, IL4, IL13
TLR4 recognizes what?
Gram negative (LPS)