Flashcards in Introduction To The Immune System Deck (28):
What causes digeorge syndrome?
Contiguous deletion of 22q11.21 through 22q11.23
What are some symptoms of digeorge syndrome?
Thymic hypoplasia or asplasia, hypoparathyroidism, congenital caridac malformation, characteristic faces sometimes cleft palate
Degree of immunodeficiency varies considerably with Digeorge syndrome based on what?
Degree of thymus loss
What are patients with Digeorge syndrome susceptible to?
Intracellular infections —> they don’t have a fully functional thymus
What antibodies types are responsible for inflammation?
IgG and IgM
The mother provides which isotope of antibody to the fetus?
What isotope is given to the baby in breast milk?
What is the signature cytokine(s) in Th1?
What is the signature cytokine(s) of Th2?
IL4, IL5, IL13
What cytokine(s) are secreted by Th17 cells?
IL17a, IL17f, IL22
Th1 functions primarily in production of ________ and the activation of what?
Th1 protects from what?
What is the role of Th1 in diseases?
Autoimmune, tissue damage associated with chronic infections
What are the immune reactions of Th2?
Mast cell and eosinophil activation, IgE production, alternative macrophage activation
What does IgE primarily play a role in
What does Th2 defend against?
What is the role of Th2 in diseases?
What is the immune reaction of Th17?
Neutrophilic and monocytic inflammation
What is the role of Th17 in host defense ?
Extracellular bacteria and fungi
What is the role of Th17 in disease?
Autoimmune inflammatory diseases
What is presented to a naive CD4+ t-cell to become a Th1?
What is the activation signal for macrophages?
CD8+ t-cells are also known as what?
Cytotoxic t-cells and they use lytic granules to kill the cells to which they bind
B cells have what signals on them?
All t cells have what CD
T helper cells have what CD
T regulatory cells have what CD on them?
3, 4, 25, IL-10, TGF-beta