Introduction To The Immune System Flashcards Preview

HDM Midterm - Brett > Introduction To The Immune System > Flashcards

Flashcards in Introduction To The Immune System Deck (28):
1

What causes digeorge syndrome?

Contiguous deletion of 22q11.21 through 22q11.23

2

What are some symptoms of digeorge syndrome?

Thymic hypoplasia or asplasia, hypoparathyroidism, congenital caridac malformation, characteristic faces sometimes cleft palate

3

Degree of immunodeficiency varies considerably with Digeorge syndrome based on what?

Degree of thymus loss

4

What are patients with Digeorge syndrome susceptible to?

Intracellular infections —> they don’t have a fully functional thymus

5

What antibodies types are responsible for inflammation?

IgG and IgM

6

The mother provides which isotope of antibody to the fetus?

IgG

7

What isotope is given to the baby in breast milk?

IgA

8

What is the signature cytokine(s) in Th1?

IFN-gamma

9

What is the signature cytokine(s) of Th2?

IL4, IL5, IL13

10

What cytokine(s) are secreted by Th17 cells?

IL17a, IL17f, IL22

11

Th1 functions primarily in production of ________ and the activation of what?

IgG, macrophage

12

Th1 protects from what?

Intracellular microbes

13

What is the role of Th1 in diseases?

Autoimmune, tissue damage associated with chronic infections

14

What are the immune reactions of Th2?

Mast cell and eosinophil activation, IgE production, alternative macrophage activation

15

What does IgE primarily play a role in

Atopic diseases

16

What does Th2 defend against?

Helminthic parasites

17

What is the role of Th2 in diseases?

Allergies

18

What is the immune reaction of Th17?

Neutrophilic and monocytic inflammation

19

What is the role of Th17 in host defense ?

Extracellular bacteria and fungi

20

What is the role of Th17 in disease?

Autoimmune inflammatory diseases

21

What is presented to a naive CD4+ t-cell to become a Th1?

IL12

22

What is the activation signal for macrophages?

IFN-gamma

23

CD8+ t-cells are also known as what?

Cytotoxic t-cells and they use lytic granules to kill the cells to which they bind

24

B cells have what signals on them?

CD19, CD21

25

All t cells have what CD

3

26

T helper cells have what CD

3, 4

27

T regulatory cells have what CD on them?

3, 4, 25, IL-10, TGF-beta

28

Cytotoxic t cells express what CD?

3, 8