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Flashcards in Ion transport Deck (76)
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1

(blank) only occurs from the glomerulus into the bowman’s space.

filtration

2

(blank) is when substance moves from tubule into peritubular capillaries

Reabsorption

3

(blank) is the movement of substance from the peritubular capillaries into the tubule

secretion

4

(blank) is the movement of substance into the urine

excretion

5

(blank) is the travel through the tight junctions of the cells.
(blank) is the travel through the cell

Paracellular
Transcellular

6

What are the three kind of active transport?

Primary-> carrier transport (H+ATPase)
Secondary (coupled transport)-> symport (Na+/Cl-) and antiport (Na+/H+)

7

What are the two types of passive transport?

Simple diffusion (Ca2+) and facilitated diffusion (urea) (uniport)

8

The (blank) provides the energy for Na to move- which allows other molecules to move with or against Na (symport/anitport)

Na/K ATPase

9

Movement of Na is down an (blank) gradient. Na allows for secondary transport.

electrical chemical

10

In the lumen of the proximal tubule Na allows for what?

allows for symport with glucose, AA and others out of the proximal tubule, and allows for antiport with H+ allowing hydrogen to enter the tubule
Potassium reabsorbed too
Also Water reabsorption and reabsorption of HCO3

11

In the thick ascending loop of henle what does sodium allow for?

reabsorption of
Na Cl, K via Symport co transporter

12

In the distal convoluted tubule what does sodium allow for?

Cl-, Ca, water to leave the lumen of the distal tubule and for Potassium to enter it.

13

What does sodium allow for in the collecting duct?

just itself to leave the collecting duct
Potassium may be reabsorbed (H, K atpase) or secreted (Na K Atpase) depending on body needs

14

Where does the majority of reabsorption of Na+ happen? Does the amount of reabsorption increase or decrease and you move down through the nephron?

in the proximal tubule (67%)
There is less reabsorption as you go down through the nephron

15

How does water flow throughout the nephron?

it follows the sodium

16

Almost all Na+ is (blank). How do you know if you are dehydrated?

reabsorbed!! (i.e almost none is excreted
If there is NONE at ALL sodium excreted

17

Movement of Cl- into cells is (blank) an electrochemical gradient.

Up

18

Movement of Na into cells is (blank) an electrochemical gradient.

down

19

How can Cl- get into the peritubular lumen?

symport with potassium

20

Does Cl- transport in or our of the collecting duct?

It doesnt do anything in the collecting duct

21

When does Cl leave the lumen of the nephron?
When does Cl enter the peritubular capillaries

-In the proximal tubule, thick ascending loop of henle, distal convoluted tubule
-In the proximal tubule, thick ascending loop of henle, distal convoluted tubule

22

What kind of transport do chloride ions use in the proximal tubule?

Passive transport (more than 50%) of the time due to Na+ and Water resorption messing with the gradient and sometimes via secondary transport

23

In the proximal tubule Na+ reabsorption increases so what happens next?

Water reabsorption and increased luminal Cl- Concentration and increased Urea concentrion which gives the lumen a more negative potential which allows for passive Cl- reabsorption and passive urea reabsorption

24

at one on a TF/P by %proximal tubule length graph denotes what?

the concentration of these substrates in the tubular fluid is the same as it is in the plasma

25

Na is a (blank) process

isosmotic process

26

What does the clearance rate of inulin tell you?

gives you the GFR

27

Explain how the TF/P by %proximal tubule length graph works.

as you move along the proximal tubule you are having water reabsorbed at a certain rate. Therefore if substances are getting reabsorbed at the same rate (like Na) then they be equally concentrated throughout the tube. However if substances aren't getting reabsorbed at the same rate, then the water will leave the tube and the substance will therefore be more concentrated and as such their line will be very steep and positive. If substances are getting reabsorbed faster than water than their line will b negative

28

According to the TF/P by %proximal tubule length graph, what get reabsorbed quickly?
Slowly?
As fast as water?

Glucose, AA, HCO3-
PAH, Inulin, Cl-
K+, Na+

29

When you put in a certain amount of potassium you need to get out that same amount. This is called (blank)

potassium homeostasis

30

What potassium level do you want to maintain?

4.2