Flashcards in Keef other transport Deck (60)
(blank) is the highest rate at which the renal tubules can transfer a substance either from the tubular luminal fluid to the interstitial fluid or from the interstitial fluid to the tubular luminal fluid.
transport maximum (TM)
(blank) reach a maximum where they can no longer move substances anymore
What substance has the highest transport maximum?
What substance as the lowest transport maximum?
Do you normally have glucose in your urine?
Where does glucose get reabsorbed into our body?
in the proxial tubule
Do you need energy to get glucose out of the tubule?
To get glucose into the peritubular capillary do you need energy?
no, done via faciliated diffusion
What is the equation for reabsorption rate?
Tx=Filtered load - excretion rate
Tx= reabsorption rate
What is the equation for excretion rate?
Ux * V
Ux= substance concentration in urine times urine flow rate
What is the equation for filtered load?
GFR times concentration of substance in plasma
What is the typically urine flow rate?
What is the typically GFR?
What percent of stuff is filtered?
If you are below the Tm what percent of substance of glucose will be present in the urine?
Some amount will be present
What is the relationship between filtration rate and plasma concentration of glucose?
directly proportional (i.e freely filtered)
What is splay?
the point at which glucose may be present in urine before the TM is reached
What does the reabsorption rate vs Plasma concetration graph show you?
shows you the Tm when the graph plateaus by showing that at a particular plasma concentration you resorption rate becomesconstant even with increasing plasma concentration (i.e you cannot reabsorb anymore)
The excretion rate vs plasma concentration graph of glucose will tell you what?
at a certain plasma concentration you will get excretion into urine
The difference between filtered load and the excretion rate is the rate of (blank)
net reabsorption or net secrion
If the filtered load is greater than the excretion rate, there has been net (blank) of the substance
If the filtered load is less than the excretion rate, there has been net (blank) of the substance.
Sodium is an example of a substance with net (blank)
PAH is an example of a substance with net (blank)
If you use sodium-glucose co transporter 2 (SCLT2) inhibitors and non selectiveblockers what will happen to your glucose reabsorption?
you will have a lot less and you will excrete a lot of glucose
If you have more glucose in the proximal tubule, what will happen to sodium?
you will have more sodium in the proximal tubule
If macula densa sense a decrease in NaCl what will happen?
you will get increased GFR via constriction of efferent and dialation of afferent
Why do you pea a lot when you have diabetes?
Mellitus: Increased osmolality of glucose ions reduces water reabsorption
Insipidous: Problems reabsorbing water
If you have a substance with a clearance rate less than inulin then you will (blank) that substance.
If you have a substance with a clearance rate higher than inulin then you will (blank) that substance
excrete it easily