Ipratropium Bromide

Question 1

What is ipratropium bromide?

Answer 1

Ipratropium bromide (250 microg/1 mL nebule) is an antimuscarinic agent which promotes bronchodilation by inhibiting cholinergic bronchomotor tone.

Onset - 1.5 to 3 min
Duration - 4-6 hours
Half-life - 3 hours

Hepatic metabolism, excreted by the kidneys.

Question 2

Indications for ipratropium bromide?

Answer 2

1. Moderate bronchospasm (unresponsive to initial QAS salbutamol NEB)
2. Severe bronchospasm

Question 3

Contraindications for ipratropium bromide?

Answer 3

1. Allergy/ADR
2. Patients less than 1 yr

Question 4

Precautions for ipratropium bromide?

Answer 4

1. Glaucoma

Question 5

Side effects of ipratropium bromide?

Answer 5

1. Dilated pupils
2. Dry mouth
3. Palpitations

Question 6

What is the dose of ipratropium bromide for an adult?

Answer 6

500 microg NEB
Repeated at 20 min intervals
Total max dose 1.5 mg

MUST BE MIXED WITH SALBUTAMOL NEB

Question 7

What is the dose of ipratropium bromide for a paediatric?

Answer 7

1 to 5 years - 250 microg NEB
Repeated at 20 min intervals
Total max dose 750 microg

> 6 years - 500 microg
Repeated at 20 min intervals
Total max dose 1.5 mg

MUST BE MIXED WITH SALBUTAMOL NEB