January Flashcards
Minerals and Food Labelling
What are minerals?
Inorganic elements that originate in the earth and cannot be made by living organism
What must minerals be attached to for humans to be able to absorb it?
organic compounds, containing carbon (these are then removed so the mineral can be utilised by the body)
how much of our body weight is minerals?
4-5%
What two minerals make up the most of the minerals in our bodies?
Calcium and phosphorus
What are the seven macrominerals?
Calcium, phosphorus, magnesium, potassium, sodium, chloride, sulphur
What are the 11 trace minerals?
iron, zinc, iodine, selenium, manganese, molybdenum, copper, chromium, boron, fluoride, silicon
What minerals exist as cations?
positively charged: potassium, magnesium, calcium, sodium
What minerals exist as anions?
negatively charged: chloride, sulphate, phosphate
What factors affect mineral bioavailability?
- mineral status in the body (if low minerals, the body makes more transport proteins)
- substances present in foods (ascorbic acid, phytates can enhance or inhibit absorption)
- other minerals present in foods (they can compete)
Which metals commonly compete for absorption?
Zn and Fe, Zn and Cu
What is a ligand?
A molecule that binds to another molecule
What are some common mineral carriers used in supplements?
Organic: citrate, ascorbate, gluconate, glycinate
Inorganic: oxide, carbonate, sulphide, chloride
What mineral is the most abundant in the body?
Calcium
What are the functions of calcium?
- building and preserving bone mass
- synapses
- cardiac muscle function and vasoconstriction
- used for binding of actin and myosin
- needed to activate vitamin-dependent clotting factors
- required for conversion of tryptophan to serotonin
What regulates calcium levels?
Parathyroid hormone (increases serum Ca)
Vitamin D (increases serum Ca)
Calcitonin (lowers serum Ca, puts it in the bones)
What food sources are high in calcium?
dark and cruciferous veg, nuts and seeds, beans, dairy, herbs
How does the bioavailability of calcium in veg and dairy differ?
Calcium in veg is absorbed 2x as efficently
Where is calcium mostly absorbed?
In the duodenum
How does vitamin D affect calcium absorption?
Vit D (calcitriol), binds to enterocytes and increases calcium transporters
What factors decrease calcium absorption?
- low vitamin D
- low stomach acid
- high phytates and oxalates
- GI dysfunction
- other minerals competing (Mg, Fe, Zn)
What factors increase calcium excretion?
- menopause (low oestrogen)
- high animal protein diets (high urea, and sulphuric acid)
- high salt
- high caffeine
What are the disadvantages of using cows milk as a source of calcium
It is high in sulphur-based amino acids that cause calcium to be leached from the bones
What are natural ways of increasing calcium?
Optimise vit D and K levels
increase plant-based calcium rich foods
What is the maximum amount of calcium absorbed in one sitting?
500mg
What are the negatives of calcium supplementation?
it can increase risk of kidney stones, soft tissue calcification
Which minerals does calcium interfere with the absorption of?
Mg, Fe, Zn, P
What foods are high in magnesium?
Leafy greens, nuts and seeds, beans, whole grains, cacao powder
What are the functions of magnesium?
- converting ADP to ATP
- needed for glucose metabolism - role in insulin sensitivity
- ion transport and conduction of nerve impulses
- Mg inhibits blood clotting
- helps making tooth enamel
- breaks actin-myosin bonds
- cofactor for GABA and serotonin-melatonin (sleep)
Where is magnesium absorbed?
In the Ileum
What foods inhibit magnesium absorption?
high-phytate foods and calcium
Why are serum magnesium levels not accurate?
Most magnesium is stored in the cells and blood concentration does not affect this
Which form of magnesium is best for constipation?
Magnesium citrate
What is the tolerable upper limit of magnesium supplements?
400mg (can cause diarrhoea in high amounts)
What form of magnesium is in epsom salts?
Magnesium sulphate
What condition should you use magnesium with caution?
hypotension
What are the symptoms of magnesium insufficiency?
fatigue, insomnia, anxiety, depression, hypertension, muscle cramps, headaches, palpitations
What key reactions is zinc a cofactor for?
Antioxidant (superoxide dismutase), alcohol dehydrogenase, digestion of proteins, haem synthesis, folate absorption, DNA synthesis
What food sources are high in zinc?
oysters, nuts and seeds (sesame), grains (rye), calf’s liver, legumes (chickpeas)
What are the key functions of zinc?
- production of sex hormones, spermatogenesis and prostatic fluids
- inhibits 5-alpha reductase
- needed for T4-T3 conversion
- Needed for cell proliferation (skin)
- Senses
- antioxidant, anti-inflammatory, anti-viral
- needed for production of HCl, and pancreatic enzymes
What food aids zinc absorption?
Proteins
What foods can reduce zinc absorption?
Foods high in phytates (legumes, whole grains, nuts and seeds - that have not been soaked)
What are the signs and symptoms of zinc deficiency?
poor sense of taste and smell, recurrent infections, skin disorders, low libido, signs of weak digestion
What is the supplemental range for zinc?
15-25mg a day - with food
What is the tolerable upper limit for Zinc?
40mg - long term
Where is most phosphorus stored in the body?
As hydroxyapatite in the bones and teeth
What are the negatives of high phosphoric acid?
it can cause calcium to leach from the bones
What are the functions of ATP?
- part of ATP, bones, teeth, DNA
- creatine phosphate is a storage unit of energy in muscles
- phospholipids in cell membranes
What are the effects of high phosphates?
hyperactivity in children
What foods are high in phosphorus?
carbonated drinks, processed food, fast food
What food sources are high in potassium?
raw spinach, potato skins, avocado, quinoa, pistachio, clams, calf’s liver
What are the key functions of potassium?
- nerve transmission, muscle function
- cofactor for energy metabolism, glycogenesis, cellular growth and division
What is the amount of potatssum required daily?
2g
What are common causes of potassium deficiency?
Diuretics, diarrhoea, vomiting, laxative abuse, chronic renal disease
What are the symptoms of low potassium?
- muscle cramps/weakness
- hypertension
- confusion
- thirst
- insomnia
What are the signs of chronic potassium toxicity?
cardiac irregularities, paralysis of extremities, confusion, tingling, weakness, kidney failure
What are three general functions of minerals in the body?
to build tissues, to maintain nerve and muscle function, to make thyroid hormones
Which mineral competes with zinc for absorption?
Copper
What is table salt made from?
40% sodium, 60% chloride by weight
What are the bad things about table salt?
- it is heat treated and bleached and anti-caking agents like aluminium are added
- It has no nutritional value
What are the pros and cons of sea salt?
- unprocessed so has a high mineral content
- may contain heavy metals and impurities
What are the benefits of himalayan sea salt?
It contains 84 trace minerals in a good ratio
the trace minerals have therapeutic benefits
What are the benefits of grey/celtic salt?
It has a similar nutritional profile to Himalayan salt, high in minerals and moisture
What hormones increase sodium levels in the body?
Renin, Aldosterone (increases sodium reabsorption and absorption)
Which hormone lowers sodium levels?
ADH
What is the minimum requirement of salt?
500mg
What is the best way to reduce sodium intake?
eating whole foods
What are the key functions of NaCl?
- Maintaining acid-alkaline balance
- nerve impulse transmission
- controls muscle contractions
- part of HCl
What are the causes of NaCl deficiency?
- persistent diarrhoea
- overuse of diuretics
- vomiting
- anorexia
- major trauma
Which people are more sensitive high salt intake?
- CKD
- Diabetes mellitus
- obese people
- those over 50yrs
- those of african origin
How much iron is there in the body?
3-4g
What two forms of iron exist in the body?
ferrous (Fe2+) and ferric (Fe3+) iron
What are the two types of iron in food?
- non-haem iron: Fe3+ plants and animals
- haem iron: Fe2+ only animals
What foods are high in iron?
- quinoa, amaranth, soybeans, spinach, pumpkin, clams