November Flashcards
How many times should you chew food?
20 times
Which antibodies are found in saliva?
IgA
What can lower the pH of the mouth?
refined sugars, meat, dairy, processed foods, gum, cigarettes, alcohol, coffee, stress
What causes the release of gastrin?
the stretching of the stomach and stimulation of enteric nerves
What does gastrin do?
stimulates peristalsis and release of HCl and digestive enzymes (lipase and pepsinogen) it also stimulates the release of bile
What enzymes are released in the stomach?
lipase and pepsinogen
Which cells release enzymes into the stomach?
Chief cells
What is the inactive form of pepsin?
Pepsinogen (converted by HCl)
What gets absorbed in the stomach?
alcohol, water, iodine and fluoride
What nutrients are needed to produce HCl?
Zinc, vitamin B6
What are some good sources of zinc?
pumpkin seeds, nuts, eggs, oysters, fish and meat
What are some good sources of B6?
sunflower seeds, whole grains, walnuts, green veg, avocado, potatoes, carrots and fish
What causes the release of CCK from I cells in duodenum?
presence of fat and protein in the stomach
What does CCK do?
Causes release of enzymes from the gallbladder and pancreas and delays gastric emptying
What are some causes of low HCl?
chronic stress (raised sympathetic activity), low B6 and zinc, autoimmune gastritis, PPIs, H.Pylori infection, ageing
What can a central line down the tongue indicate?
poor gastric function
What issues can occur due to low stomach acid?
protein putrefaction creates polyamines
undigested food can cause SIBO
Reduced gastric activity reduces intrinsic factor compromising B12 absorption
What are the symptoms of low stomach acid?
bloating, belching and flatulence
abdominal pain and fullness after eating
How can you naturally increase stomach acid?
Apple cider vinegar with water before meals
bitter herbs and foods
zinc and B6 rich foods
fermented vegetables
Which herbs are bitter?
Gentian, barberry bark, rocket, dandelion, goldenseal, chicory, artichoke
What causes CCK release?
The presence of acidic chyme in the duodenum
What is the pH of the duodenum?
6.5
Where does the majority of absorption take place?
In the small intestine - jejunum
In which part of the digestive tract is vitamin B12 absorbed?
The ileum
Which enzymes are found on the brush border?
maltase, sucrase, lactase and dipeptidase (breaks down disaccharides and dipeptides)
Where do fatty acids get absorbed into?
The lymphatic capillaries
How much pancreatic juice is produced per day?
1.2-1.5L
What enzymes are produced by the pancreas?
amylase, lipase and proteases - trypsin and chymotrypsin
What symptoms can occur if pancreatic enzyme production is poor?
food ferments in intestine causing - bloating, flatulence and abdominal pain an hour after eating
What observations did Bernard Jensen make about overeating?
he found that undigested materials are stored in the mucous-secreting lining of the intestines, impairing absorption
What is in bile?
water, bile salts (conjugated with glycine and taurine), cholesterol and bilirubin
What causes bile release?
The presence of fat in the duodenum
What are the functions of bile?
Fat emulsification, carries detoxified products from the liver, stimulates peristalsis, excretes excess cholersterol
What does the liver store?
Glycogen, fats, iron, vitamins ADEK and B12
What can you use to reduce EMF?
Shungite stone
What is a phase 1 reaction?
the breakdown of toxins into smaller substances
Which enzymes are involved in phase 1 reactions?
CYP450 - they create an active binding site on the toxin
What are the by-products of phase 1 reactions?
Free radicals, toxic compounds
What are phase 2 reactions?
conjugation reactions, they modify toxins to make them safe and excretable by binding a functional group to them
What nutrients are needed for phase 1 reactions?
Antioxidants e.g. beta carotene, vit C
What nutrients are needed for phase 2 reactions?
sulphur, magnesium, B vitamins
What is the key antioxidant used in phase 2 reactions?
glutathione (selenium is needed for the production of glutathione peroxidase)
What is the most potent antioxidant?
Melatonin
What ingredients can you use in a liver flush?
lemon juice, orange juice, apple juice, olive oil, ginger, cayenne pepper
Which cells produce mucus in the large intestine?
goblet cells
Where is vitamin B12 absorbed?
In the terminal ileum
Where is the gut associated lymphoid tissue found?
In the lamina propria - beneath the epithelium of the intestinal wall
What is found in the gut associated lymphoid tissue?
Macrophages and lymphocytes
What type of antibody is secreted by gut associated lymphoid tissue?
IgA
What supplement can you give to improve IgA levels in the gut?
Saccharomyces Boulardii
How are the final nutrients of food extracted?
microbial fermentation
What are the by-products of microbial fermentation?
methane, hydrogen, hydrogen sulphide
What can early weaning cause?
overstimulation of the immune system in response to foods
What are the functions of the gut microflora?
synthesises vitamins (biotin and K2), supports intestinal barrier (produce short-chain fatty acids), outcompetes pathogenic bacteria, immune function, regulates appetite, mood regulation
What factors can contribute to leaky gut?
processed foods, refined sugars, heavy metals, corticosteroids, NSAIDs, Abx, stress, dysbiosis, alcohol and smoking, radiation and chemotherapy, early weaning
What is an inflammatory marker of the gut?
faecal calprotectin