JK L2 eukaryote gene expression Flashcards Preview

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Flashcards in JK L2 eukaryote gene expression Deck (5)
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1

how do eukaryotes regulate gene expression...?

direct- interaction with transcriptional machinery

indirect- changing chromatin structure, opening up diff areas of the chromosome allowing transcription factors to get into the promoter

2

what does the phosphorylation of TFIIH lead to...?

the start of RNA synthesis

3

TATA binding protein binds....where?

to the core promoter to enable RNA pol II and other transcription factors to bind

4

info on TATA box

TATA box indirectly positions RNA pol II to begin transcription which is positioned around 30bp downstream

5

TF's which will help determine the level of transcription from the preinitiation complex

Ø TF that bind close to promoter
Ø TF that bind far away from promoter (called enhancers)
Ø Some which will act negatively and are far away called silencers
Ø Close binders will be specific for this promoter

Far away binders might be controlling more than one promoter