Flashcards in key terms final Deck (73)
what do you use for antimicrobial prophylaxis in a clean orthopedic procedure?
How do volatile anesthetics affect coronary blood flow?
Iso is a potent coronary vasodilator, may cause coronary steal
Other volatiles are weak coronary vasodilators
What is the clinical use of phentoalamine?
nonselective Competitive alpha blocker used in acute hypertensive emergency, i.e. pheochromocytoma or autonimic nervous system hyperreflecxia
What are the side effects of protamine?
What is the mechanism of action of ondansetron?
What is used for antimicrobial prophylaxis in head and neck surgery in a pt with a cephalosporin allergy?
clinda (600-900)+ genta (1.5mg/kg)
How is flumazenil metabolized?
What is the mechanism of action of coumadin?
Vitamin K antagonist causes defective vitamin K factors (2,7,9,10)
Which opioid is associated with siezure?
Which beta blocker is used to treat glaucoma?
What is the potency of opioids from least potent to most?
How is metformin metabolized?
Cleared by kidneys 100% unchanged
Which is the quickest acting opioid?
Remifentanyl--6-12 min duration
Which drugs are examples of class IV?
Verapamil and Diltiazem
Lidocaine is used to tx _______ arrhythmias
At what receptor occupancy does midazolam cause
What is the onset of edrophonium?
shortest of the anticholinesterase
What is the mechanism of class IV antidysrhythmics?
Ca+ channel blockers
decrease action potential duration
What is the effect of induction drugs on ICP?
Which opioids should you not use in a pt with renal failure?
merperidine and morphine
What is the order of volatile agents from lowest blood:gas coefficient to highest
What are examples of oral anticoagulants?
coumadin and pradaxa
How much cardiac output goes to each of the tissue groups?
What is the duration of action for regular insulin?
What is the mOA for Hirudin?
direct thrombin inhibitior: Supresses platelet function
What is the order of most metabolized to least metabolized volatile anesthetics?
Halothane-20%>Sevo 2-5%>Iso .2%>Des 0
HOw do NSAIDS work and what happens if you give a whole lot?
Inhibition of both cyclooxygenase without specificity
ceiling effect--exceeding recommended dose only adds to risk of toxicity
What determines the rate local anesthetics are absorbed?
site of injection
drug tissue binding
local blood flow
addition of a vasocontrictor
What is the mechanism of action of histamine antagonists?
Antagonize histamine receptor/ do not decrease amount of histamine (except H3)
What is the pH of thiopental?
What is the side effect of sulfonylureas?
Which local anesthetics cause methemoglobinemia?
prilocaine and benzocaine
What is the concentration for epi added to local anesthetics?
1:200000 aka 5mcg/ml
What does NPH stand for ?
neutral protamine hagedorn
What is the toxic dose of lidocaine without epi?
What is the treatment for methemoglobinemia?
methylene blue 1-2 mg
What is Im dose for induction with ketamine?
what are contraindications for droperidol?
prolonged QT and parkinsons
What is toxic doses of bupivicaine w/ and w/out epi?
What is the gold standard K+ sparing diuretic?
(amiloride was the other one listed as an example)
What does VRE stand for?
Vancomycin resistant enterococcus
What does MRSA stand for
methicillin resistant staphylococcus aureus
What is the intubating dose for cisatracurium?
What do you give for Anticholinergic overdose?
What infusion rates of epi are associated with alpha1?
Alpha1 1-2 mcg/min
Beta2 10-20 mcg/min
In the 2006 medical letter guidelines which antibiotic is indicated for bowel procedures?
What do you give to treat biliary colic from opioids?
glucagon 2mg iv
Which opioid receptor do enkalphalins bind to?
Which opioid receptor do dynorphins bind to?
Which opioid receptor is associated with feeling of dysphoria?
kappa--where agonist/antagonist work
which opioid has atropine like effects?
Which diurectic is prescribed for IOP?
acetazolamide--carbonic anhydrase inhibitior
how is esmolol metabolized?
what is ped dosage of ondansetron?
what is papaverin used for?
used by vascular surgeons not really us
(verapamil is derived from papavirine)
what drug is contraindicated in porphyria>?
Which diuretic is prescribed for essential hyperetension?
Which antibiotic is given for prophylaxis in a C section?
(clinda and genta also listed)
How are opiods metabolized? whats the exception?
all hepatic except Remi-plasma and tissue esterases
which ca++ channel blocker provides the best vasodilation?
which Ca++ channel blocker is used for cerebral vasospasm?
At what dose of SNP do you start sseing CN accumulation?
(regular dose is 0.3-10 mcg/kg/min
what is ratio of beta:alpha in labetalol?
name 2 alpha 2 agonists
clonidine alpha2:1 200:1
which antacid does not cause acid rebound?
which nsaid is used to close a PDA?
what are the effects of Beta 2 agonist?
Increased glucose secretion
gluconeogenesis ad glycogenolysis are inhibited
How do volatile anesthetics affect cerebral blood flow?
Which inhaled agent causes bone marrow supression?
What is the formula for uptake?
solubility x CO x (Pa-Pv)
which induction agent causes adrenocorticoid supression?
other sides: myoclonus, hiccups, increased PONV
which H2 blocker inhibits cytochrome p450 nand may delay lido metabolism