Klebsiella Pneumoniae Flashcards Preview

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Flashcards in Klebsiella Pneumoniae Deck (20):
1

Enterobacteriaceae characteristics

Glucose fermenters, catalase positive, oxidase negative,

2

How to distinguish K. pneumoniae from E. coli?

K. pneumoniae is indole negative

3

Where are klebsiella located?

Human lower GI tract, skin, and female genitals. Produce disease when access sterile sites.

4

What does Klebsiella pneumoniae cause?

UTI, pneumonia, intra-abdominal infections

5

Klebsiella on MacConkey plate.

Lactose fermenter (like E. coli) produce pink colonies.

6

Klebsiella characteristics under microscope

Non-motile, encapsulated (virulence factor), gram negative bacilli.

7

Describe Klebsiella capsule

Mucoid polysaccharide capsule to evade phagocytosis. Has hypermucoviscous isolates, string test. Must important virulence factor.

8

O antigen

LPS

9

Siderophore

Another main virulence factor, capable of sequestering iron

10

Type 1 pili

Mediates adherence to epithelium

11

Type 3 pili

Mediates bilifilm production

12

Pneumonia caused by Klebsiella

Hemorrhagic, necrotizing upper lobar pneumonia, associated with somewhat immunocompromised hosts (diabetes), very deadly (50% mortality)

13

Spontaneous peritonitis

Common in patients with cirrhosis and other liver diseases (Klebsiella is the 3rd most common isolated organism)

14

Secondary peritonitis

Associated with abdominal organ inflammation (generally after surgery). Klebsiella is the 2nd most commonly isolated organism.

15

Is Klebsiella a common cause of UTI?

Yes (6-12%), after E coli.

16

Can Klebsiella be treated with ampicillin?

No, resistant.

17

Can Klebsiella be treated by any penicillin?

Yes, the anti-pseudomonal penicillins, eg: piperacillin. Has good gram negative coverage. Often combined with a beta lactamase inhibitor

18

Anti-pseudomonal penicillin and beta lactamase inhibitor

Piperacillin-tazobactam.

19

Which cephalosporin(s) treat K. pneumoniae?

Cefepime. Has excellent gram positive activity, stable against beta lactamases. Good against pseudomonas

20

Which organisms have chromosomal inducible beta lactamase (ampC)

SPICE. Serratia, pseudomonas aeruginosa, indole positive proteaceae, citrobacter, enterobacter