Pseudomonas Aeruginosa Flashcards Preview

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Flashcards in Pseudomonas Aeruginosa Deck (15):
1

Can P. aeruginosa ferment lactose? What is an example of the opposite?

No! E. Coli can.

2

Is pseudomonas oxidase positive or negative?

Oxidase positive

3

Is P. aeruginosa mucoid or non-mucoid?

It can be both, mucoid is worse.

4

What are the cellular structures that P. aeruginosa has?

Flagellum, pili!

5

What are some other virulence factors of P. aeruginosa.

LPS, siderophores, exotoxins, exoenximes, pyocianin

6

Who has special susceptibility to pseudomonas?

Patients with burns, patients with CF, patients with diabetes, and patients on chemo.

7

Clinical manifestations of P. aeruginosa

Bacteremia, endocarditis, folliculitis, otitis externa, respiratory infections.

8

Most common CFTR gene mutation?

DeltaF508

9

Common CF infections from least terrible to most?

S.Aureus, H influenzae, pseudomonas aeruginosa (nonmucoid), mucoid p. aeruginosa, burkholderia cepacia.

10

Why does CF lead to increased infection?

Abnormal CFTR causes abnormal epithelial cell function, which causes thickened secretions, allow bacterial colonization, increase in inflammatory cytokines, cell injury.

11

Antimicrobial agents for pseudomonas

Piperacillin/tazobactam, cetazidime, cefepime, imipenem-cilastatin, aztreonam, gentamicin,

12

Burkholderia cepacia causes...?

Catheter associated bacteremia, ventilator associated pneumonia

13

Stenotrophomonas maltophilia causes?

Catheter associated bacteremia, ventilator associated pneumonia.

14

Aminoglycosides

Streptomycin, gentamycin, tobramycin, amikacin

15

Where do most nosocomial infections occur?

Burn units, newborn ICU, M and S ICU, Oncology units.