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Flashcards in Krebs cycle Deck (7)
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1
Q

When is aerobic glycolysis seen?

A

in invasive cancers

2
Q

What does aerobic glycolysis do?

A

converts glucose into lactic acid in the presence of oxygen

3
Q

Why do cancer cells use aerobic glycolysis?

A

because running fast glycolysis creates intra-and pericellular acidic conditions, which tumor cells proliferate in. Normal cells cannot adapt to acidic conditions

4
Q

What kind of cells do end stage metastases favor?

A

glycolytic cells and cells resistant to hypoxia

5
Q

Are early tumors vascular?

A

Not before breaching the basement membrane. It can tolerate anaerobic conditions

6
Q

What occurs during the aerobic metabolism of a carb?

A

electrons are taken from carbohydrates and given to oxygen in the electron transport system

7
Q

What occurs during fermentation of a carbohydrate?

A

electrons are taken from carbohydrates and given back while making ATP. This is anaerobic and the products are 2 lactate and 2 ethanol