L11- Mucosa 1 Flashcards
(38 cards)
Bame some glands wbich are mucosal surfsces and effector sites
Lacrimal, salivary and mammary glands
What are the rxamples of hoe mucosa fscilitate exchange
Food processing, gas exchnage, teporhdction and metabolic waste
Which mucosa is the largest
Resp tract (75m2)
Why are ststemic vaccines used also for mucosal issues
When pathogens cross barriers cause for systemic immunity
Name some mucosal infrctions related to hugh morbidity and mortality
Copd, hiv, lower resp trsct infdctions eg infleunza, pneumonia
What mechanical mucosal defences are there
Tight junctions, mucus
Which ros can microbiota release and why is this anti microbial?
H202, it means they xan be detected by prr inducing , and also oxidative dna damage
Which secretion eg by lactobacillus is antiviral
Lactic acid
Other than defensins. What protects the gut
Low ph wnd enzymes like pepsin
Where are b defensins most seen
Eye, nose and oral cavity
How does sneezing and cooghing eiminate pathogens
Muscle contraction increases mucosal movemnet cross cillia
Which mudcle contraction allows mucosal movement in gut
Peristalsis
Where are stratified epithelium found
Vaginal and oral cavity
What allows polarisation for solutr, ion and gas transport in simple columnar cells
Tight junctions
Whcih prr are on epi cells and what haplens
Nod and tlr (crll surfscr) so they modulate release of more mucins, amps etc
What do tlr and nod activate for cytokine rleease
Nfkb
What can trigger inflammasome
Intraceullar infections
What does inflammasome do
Caspases1 allow secretion of cytokines and also activstion of dc and macrophages
What is xenophagy
When bacteria/fungi/ ciruses in cytoplasm are taken up into autophagosome and killed by lysosome fusion eg in macrophages
How can nlrp3 recognise virus infected cells
Relesde of damps
Whatbis diff about effector cells like t cells/ macrophages in mucosa
Always active
Which 2 ways are mucosa immunotegulatory
Down reg responses to eg food. Eg by reducing ige
Always have tolerance ineucing dc and inhibitory macrophages
What is the ting called around aireays and gut in nalt
Waldeyers ring (adenoids and tonsils)
What makes ip galt
Pp and lymph nodules
