L18 Cell Cycle And Mitosis

Question 1

How is cell cycle controlled

Answer 1

By presence and interactions of a group of related proteins known as cyclins with specific CDKs

Question 2

When is cyclin D synthesized and what CDK does it bind to

Answer 2

G1 phase

CDK4 and CDK6

Question 3

When is cyclin E Synthesized and what CDK does it bind to

Answer 3

Late g1

CDK2

Question 4

what cdk does cyclin A bind to

Answer 4

CDK2 and CDK1

Question 5

When is cyclin B made and what CDK does it bind to

Answer 5

G2 phase

CDK1

Question 6

What is the fate of cyclins

Answer 6

Enter ubiquitin proteasome pathway where they are degraded

Question 7

Factors stimulating cell to enter cell cycle

Answer 7

Mechanical force
Cell death
Injury

Question 8

Cell cycle phases (in order) are…

Answer 8

Prophase
Metaphase
Anaphase
Telophase
Cytokinesis

Question 9

What happens during prophase

Answer 9

Chromosomes condense
Nucleolus disappears
Centrosome divides

Question 10

What happens in metaphase

Answer 10

Nuclear envelope disappears

Newly duplicated chromosomes align themselves at the equator of the mitotic spindle

Question 11

What happens during anaphase

Answer 11

Sister chromatids separate and begin to migrate to opposite poles of the cell and cleavage furrow begins to develop

Question 12

What happens in telophase

Answer 12

Chromosomes uncoil and become organized in to heterochromatin and euchromatin
Cytokinesis occurs where cleavage furrow deepens
Diploid cells form

Question 13

How does cytokinesis occur

Answer 13

Contractile ring forms composed of actin and myosin filaments attached to plasma membrane

Question 14

Drugs used to aid in cancer therapy

Answer 14

Vincristine(disrupts mitotic spindle)

Colchicine