Flashcards in L40_Fungi-1 Deck (19):
Bacteria are prokaryotes, what are fungi?
They are eukaryotic heterotrophs like humans
Why dont anti-bacterials have any efficacy against fungus?
Because most antibacterials are targets agains 70s ribosomes or the production of peptidoglycan
What are fungal walls made of?
Chitin and Beta-Glucan
What are the two major targets of antifungals?
beta-glucan and ergosterol (cholesterol analog of fungal membranes)
With respect to toxicity, describe why designing antibiotics is much harder for fungi
Antifungals usually have some toxicity in humans, there are fewer molecular targets and since fungi and humans have a much closer evolutionary relationship with humans the effects of antifungals have a lot of spill over into the human system.