L35_DNA Viruses 2 Flashcards Preview

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Flashcards in L35_DNA Viruses 2 Deck (66)
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1

Name some infections that herpesviruses cause?

Chickenpox, mononucleosis, Birth Defects, Cancer

2

How many human herpes viruses are there?

8

3

What strain is genital herpes, above the waist?

HSV 2 (genital)
HSV 1 (above waist)

4

describe the genome of herpes virus

Liner dsDNA

5

How does herpes virus enter the cell?

It binds to surface proteins and fuses or is endocytosed.

6

Where does herpes virus capsid uncoat?

The nuclear pore

7

What happens to the herpesvirus genome when it enters the nucleus?

It circularizes

8

Describe the stages of transcription of herpersvirus

Immediate Early (Transcription factors), Early (replication proteins), Late (capsid proteins)

9

Where is the capsid formed for new herpes virus virions?

In the nucleus

10

What polymerase is used for replication of herpesvirus?

The viral DNA polymerase

11

How does Herpesvirus egress?

exocytosis

12

Do all herpesviruses have the same tissue tropism?

NO

13

Where does herpesvirus get its envelope?

First from nuclear membrane, then it gets its tegument, then gets a second envelope from the trans golgi network.

14

Is the cell killed in the production of herpesvirus?

Not necessarily, cells can shed virions without being killed

15

What is the definition of latency

The genome is present in a cell but infectious virions are absent.

16

When does latency occur?

Immediately upon infection, before any symptoms present, this is why we can get rid of it once its there.

17

How is HSV1 spread?

Spread by close contact with active lesions or asymptomatic shedding

18

What type of infection usually occurs in children with HSV1?

Gingivostomatitis (lesions on mouth, face, nose, and eyes)

19

What cells does herpes virus become latent for life for both HSV1 and HSV2?

Neurons (terminal non-differentiated)

20

What is the prodrome of recurrent HSV1?

Tingling and itching

21

What can trigger an HSV1 recurrent outbreak?

Fever, sunlight, hormones, stress, physical trauma, etc.

22

Where do recurrent mouth lesions originate from?

Trigeminal ganglion.

23

What part of brain to HSV viruses tend to target?

The temporal lobe

24

What type of neurological infections can HSV cause in primary and secondary infections?

Primary- meningitis (stiff neck and headache)
Secondary- Encephalitis (Fever and Neurological symptoms)

25

How is HSV2 spread?

Spread by close contact between mucous membranes (genital and/or oral)

26

What are the symptoms of HSV2

many lesions, pain, itching, fever, malaise, headache (usually but not always below waist

27

Are double infections with HSV1 and 2 common?

Yes

28

How can you distinguish between HSV 1 and 2 in the lab?

Serology or PCR

29

Is there a way to control outbreaks?

Yes you can decrease or suppress outbreaks, many drug is Valtrex

30

Is there a vaccine for herpes simplex?

NO