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Viruses & Parasites > L78 > Flashcards

Flashcards in L78 Deck (37):
1

What is exanthem?

Rash on skin
Vs. enanthem = rash on mucous membrane

2

Big 5 childhood diseases that cause rash

Measles
Strep pyogenes
Rubella
Parvo - erythema infectiosum
Roseola (HHV 6)

3

Symptoms of measles

3 Cs + K
Conjunctivitis
Cough
Coryza = running nose
Koplic spots = enanthem rash in the mouth w/ grey middle

4

Describe the measles rash: appearance, timing

= Rubeola
Develops after Koplic spots
Starts on face
Progresses centrally
Moves to periphery & toes

5

Geographic tip offs for measles

California
Switzerland

6

Measles incubation

1 up to 2 wks
Day 10 - fever
Day 14 - rash
Infectious before symptoms start during this incubation period

7

Measles transmission

Air-born
Kids in school

8

Diagnose measles

1. Clinical
2. Serum testing - IgM/G - watch out for false +/-

9

What tissue does measles infect?

Respiratory epithelium --> LN

10

Which immune system is important for measles resolution?

Cellular

11

Measles genome

(-) ssRNA
Enveloped
Labile

12

What cell types does measles infect during primary viremia?

T cells! Same time once penetrated resp epi
Causes temp immune suppression that is definitely noticeable
- Pna

13

What CNS disease might result from measles? When might this present?

Encephalitis
Acute or sub-acute years later!

14

What nutrition deficiency would make measles worse?

Vit A def

15

When do you give the measles vaccine?

9mo-1 year
Live, attenuated vaccine - therefore babies who have mom's Abs might not have right response

16

Mumps symptoms

Swollen neck!!
Parotid gland
1 sided - may spread bilateral

17

Mumps genome

(-) ss RNA
Capsid w/
- Hemagglutinin (H)
- Neuraminidase (N)
- Fusion protein (F)
Lipid bilayer from host cells

18

Mumps pathogenesis - where does infection start and move

Start @ URT epi
to LN
Viremia -> glandular tissue (scrotum)

19

Which branch of immunity controls mumps infection?

Cellular

20

Mumps transmission

Resp drops
Saliva
Fomites

21

Mumps incubation

2-3 wks
Longer than measles

22

When is mumps contagious?

2 days before jaw swelling --> 5 days after

23

Which CNS disease is associated with mumps?

Aseptic meningitis

24

Mumps complications

Encephalitis
Deafness
Infertility

25

Mumps vaccine. Who don't you give this to?

Live, attenuated
As MMR/V
DONT give to PREGNANT

26

Rubella symptoms

Head --> toes : disappears as it progresses
- Correlates w/ appearance of Abs
Cervical swollen LN
Arthritis - esp adults

27

Rubella genome

+ ssRNA

28

Rubella pathogenesis

URT epi
LNs
Viremia

29

What is the role of Abs vs cell immunity for rubella?

Ab: limit spread
Cell: elim infection

30

Rubella incubation & infectious period

2-3 wk incubation
Infectious: prodome --> 2 wks post rash

31

What is congenital rubella syndrome?

In BABIES :(
Cataracts
Heart disease
Deafness
"Blue berry muffin rash"

32

Why do we vaccinate vs rubella?

To cover women who might become pregnant to prevent congenital rubella syndrome

33

Parvovirus symptoms - correlation to infectiousness

1. Fever due to viremia = infectious
2. Slap check rash = erythema infectiousum

34

Parvovirus genome

ss DNA

35

What cells does parvo replicate in?

Erythroid precursors
Fetal capillary endothelium in placenta

36

Parvo patho

Replicates @ RT
Viremia --> bone marrow

37

Secondary diseases that might result from parvo

Arthritis
Anemia - duh, infecting blood precursors!
Non-immune fetal hydrops !!
Myocarditis