Flashcards in L78 Deck (37):
What is exanthem?
Rash on skin
Vs. enanthem = rash on mucous membrane
Big 5 childhood diseases that cause rash
Parvo - erythema infectiosum
Roseola (HHV 6)
Symptoms of measles
3 Cs + K
Coryza = running nose
Koplic spots = enanthem rash in the mouth w/ grey middle
Describe the measles rash: appearance, timing
Develops after Koplic spots
Starts on face
Moves to periphery & toes
Geographic tip offs for measles
1 up to 2 wks
Day 10 - fever
Day 14 - rash
Infectious before symptoms start during this incubation period
Kids in school
2. Serum testing - IgM/G - watch out for false +/-
What tissue does measles infect?
Respiratory epithelium --> LN
Which immune system is important for measles resolution?
What cell types does measles infect during primary viremia?
T cells! Same time once penetrated resp epi
Causes temp immune suppression that is definitely noticeable
What CNS disease might result from measles? When might this present?
Acute or sub-acute years later!
What nutrition deficiency would make measles worse?
Vit A def
When do you give the measles vaccine?
Live, attenuated vaccine - therefore babies who have mom's Abs might not have right response
1 sided - may spread bilateral
(-) ss RNA
- Hemagglutinin (H)
- Neuraminidase (N)
- Fusion protein (F)
Lipid bilayer from host cells
Mumps pathogenesis - where does infection start and move
Start @ URT epi
Viremia -> glandular tissue (scrotum)
Which branch of immunity controls mumps infection?
Longer than measles
When is mumps contagious?
2 days before jaw swelling --> 5 days after
Which CNS disease is associated with mumps?
Mumps vaccine. Who don't you give this to?
DONT give to PREGNANT
Head --> toes : disappears as it progresses
- Correlates w/ appearance of Abs
Cervical swollen LN
Arthritis - esp adults
What is the role of Abs vs cell immunity for rubella?
Ab: limit spread
Cell: elim infection
Rubella incubation & infectious period
2-3 wk incubation
Infectious: prodome --> 2 wks post rash
What is congenital rubella syndrome?
In BABIES :(
"Blue berry muffin rash"
Why do we vaccinate vs rubella?
To cover women who might become pregnant to prevent congenital rubella syndrome
Parvovirus symptoms - correlation to infectiousness
1. Fever due to viremia = infectious
2. Slap check rash = erythema infectiousum
What cells does parvo replicate in?
Fetal capillary endothelium in placenta
Replicates @ RT
Viremia --> bone marrow