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Flashcards in L77 Deck (11):
1

Ebola's non-human reservoir

Bats

2

Will Ebola be eradicated?

No - can't kill or immunize all the bats

3

Ebola transmission

P2P - blood highest risk
Air - low risk

4

How do you make Ebola self-limiting?

Isolation protocols

5

What cells does Ebola initially infect?

DCs
Macrophages

6

When do infected people begin to be able to actively transmit Ebola?

Once symptomatic
Until symptoms, you can't even find the virus in the blood by PCR

7

What dets worse prognosis with Ebola

Higher viral load

8

What kind of disease is Ebola? What is the first symptom? What is the gimme symptom?

Viral hemorrhagic fever
Fever = most common
Bleeding anywhere = hallmark
- Not common
- Happens in late stages if at all
- Not really the life threatening aspect

9

Explain IFN therapy.

Infected cells naturally produce IFN to induce an anti-viral state in neighboring cells to prevent infection
If you give IFN as a med - you'd make host cells inhospitable to infection

10

IFN mechanism of preventing infection

Viral mRNA degradation
X ribosome assembly

11

Explain why IFN isn't the idea therapy

Some viruses make IFN antagonists (Ebola)
Dosing IFN has negative SE - changes natural immune state + fevers