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Viruses & Parasites > L80 > Flashcards

Flashcards in L80 Deck (28):
1

What viruses cause the common cold?

1. Rhinovirus
2. Corona (MERS)
Adeno
Entero
Parainflu, flu, RSV, metapneumo

2

Rhinovirus:
DNA or RNA?
Be sure to include specifics

Rhinovirus
+ ssRNA

3

What are characteristics that rhinovirus requires for optimal growth?

Cooler temps!
Nose > lungs

4

Rhinovirus attaches to host cells via....

ICAM 1

5

How does rhinovirus cause the symptoms of rhinitis & sore throat?

↑bradykinin --> ↑vasc perm of nasal submucosa
↑local PMNs

6

Does the common cold present with fever?

NO

7

Which disease presents in kids with a "barking cough"? Name the virus most likely to cause it.

Croup = acute laryngo-tracheo-bronchitis
Parainflu

8

What age group do you expect croup in?

0-6 yo

9

Parainflu:
DNA or RNA?
Include specifics

- ss RNA

10

How does influ cause the croup cough? What unique sign are you looking for?

Inflammation --> narrow trachea
Steeple sign on XR

11

Test for parainflu

Nash wash:
- Viral culture
- Immunofluoro
- PCR

12

Treat croup

Supportive

13

What disease presents with infant wheezing --> ↓oxygenation? Viral causes.

Bronchiolitis
1. RSV
2. Metapneumo
Rhino, influ, parainflu, corona

14

RSV
DNA or RNA
Be specific

- ss RNA

15

What outer proteins are unique to RSV? How does RSV change host cell morphology?

F protein = fusion
Syncitia formation = fusion of multiple cells
Leads to inflam + necrosis -> small airway obstruction -> bronchiolitis

16

When does bronchiolitis peak?

WINTER

17

Diagnose bronchiolitis

CXR - steeple sign
Pulse ox - ↓↓

18

Who and what do you use for bronchiolitis prophylaxis?

Premies = ↑risk
Palivizuman = monoclonal Ab

19

Which viral resp infection should you be particularly concerned about in ELDERLY?

Flu!!!
B/c U shaped mortality/morbidity curve
↑ hospitalization and death in the elderly

20

Flu: DNA or RNA - be specific
Types?

- ss RNA
*segmented genome
Types A-C
A & B cause illness and outbreak

21

What are the 2 targets of the flu vaccine?

HA
NA

22

What in unique about flu release in host cells?

ACIDIC
Via M2 creating proton pumps to acidify the endosome

23

Is flu epidemic caused by genetic drift or shift?

DRIFT = random mutations from RNA pol
Why we update the flu vaccine every year

24

Is flu pandemic due to genetic drift or shift?

SHIFT = reassortment that creates brand new virus
The vaccine won't help you year
Ex: H1N1 - hit young people b/c vaccine didn't cover + older people probably had some existing immunity from prior year strain

25

What 2 bugs would cause a retro-orbital headache?

Flu
Dengue Fever

26

2 tests for flu - include pros and cons of each

Rapid antigen test
- Pro = fast
- Con = can't get subtypes
PCR

27

What 3 drugs can you use to block the the spread of flu (aka not the vaccine)?

NA inhibitors: - "mivir"
Oseltamivir
Zanamivir
Peramivir

28

What mutation makes flu resistant to NA inhibitors?

H275Y = mutation in the NA gene