LAB Exercise 1b Flashcards

Factors Determining Variation in Inflammatory Response

1
Q

Factors determining variation in inflammatory response involving the organism

A
  • Type of injury and infection
  • Virulence
  • Dose
  • Portal of entry
  • Product of organisms
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2
Q

Factors determining variation in inflammatory response involving the host

A
Systemic diseases
• Immune status of host
• Congenital neutrophil defects
• Leukopenia
• Site or type of tissue involved
• Local host factors
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3
Q

5 types of exudation

A
  1. serous
  2. fibrinous
  3. purulent or suppurative
  4. hemorrhagic
  5. catarrhal
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4
Q

Considered as the mildest form of inflammation characterized by the outpouring of a thin fluid

A

serous inflammation

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5
Q

Accumulation of fluid in the peritoneal, pleural, and pericardial cavity

A

effusion

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6
Q

exudation when the fibrin content of the fluid exudate is high.

A

fibrinous inflammation

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7
Q

A fibrinous exudate is characteristic of inflammation

A

in the lining of body cavities

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8
Q

develops when the vascular leaks are large or there is a local procoagulant stimulus

A

Fibrinous Inflammation

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9
Q

develops when the vascular leaks are large or there is a local procoagulant stimulus

A

Fibrinous Inflammation

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10
Q

Exudation from the formation of creamy pus as seen in infection with pyogenic bacteria such as streptocicci or staphylococci

A

Suppurative or Purulent Inflammation

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11
Q

It is viscous yellow fluid composed of dead and dying PMNs and necrotic tissue debris. It is also rich in lytic enzymes released from leukocytes, destroyed cells, and bacteria

A

pus

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12
Q

Purulent exudate that is also rich in fibrin is said to be

A

purulent

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13
Q

localized collection of pus within an organ or tissue is called

A

abscess

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14
Q

In chronic abcsesses, the wall of an abscess is composed of a capsule consisting of

A

fibrotic granulation tissue

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15
Q

In chronic abcsesses, the wall of an abscess is composed of a capsule consisting of

A

fibrotic granulation tissue

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16
Q

A cavity, usually occupied previously by an abscess, that drains through a tract to the surface of the body when the abscess ruptures

A

sinus

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17
Q

A channel between two preexisting cavities or hollow organs that is formed when large abcesses ruptures.

A

fistula

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18
Q

Accumulation of pus in a preformed cavity

A

ampyema

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19
Q

Accumulation of pus in a preformed cavity

A

empyema

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20
Q

Inflammation that is a local defect, or excavation, of the surface of an organ or tissue that is produced by the shedding of inflamed necrotic tissue

A

ulcerative inflammation

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21
Q

Occur only when tissue necrosis and resultant inflammation exist on or near a surface

A

ulcerative inflammation

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22
Q

Morphology of cute ulcer

A

intense polymorphonuclear infiltration and vascular dilation in the margins of the defect.

23
Q

chronic ulcer morphology

A

fibroblastic proliferation
scarring
accumulation of lymphocytes, macrophages, and plasma cells.

24
Q

Imflmmtion where the exudate of fibrin, pus, cellular debris, and mucus forms a pseudomembrane on the surface of the ulcers.

A

Pseudomembranous Inflammation

25
inflammation caused by Clostridium difficile
pseudomembranous colitis
26
Four outcomes of acute inflammation
resolution healing by fibrosis abscess formation chronic inflammation
27
Outcome that involves the restitution of normal architecture and function where the connective tissue framework of the tissue is intact
resolution
28
Outcome known as scar formation occurs when there is substantial damage to the connective tissue framework and/or the tissue lacks the ability to regenerate specialized cells
Healing by fibrosis
29
Despite the loss of some specialized cells and some architectural distortion by fibrous scar, structural integrity is reestablished.
Healing by Fibrosis
30
Healing by fibrosis which occurs quickly with a small amount of granulation tissue
healing by primary intention
31
Healing by fibrosis that is large and filled with blood clot and a variable amount of tissue debris.
healing by secondary intention
32
Takes place when the acute inflammatory reaction fails to destroy/remove the cause of tissue damage and continues, and is common in the case of infection by pyogenic bacteria
Abscess formation
33
Outcome that results following acute inflammation when an injurious agent persists over a prolonged period, causing concomitant tissue destruction.
chronic inflammation
34
The hallmark features of chronic inflammation
ongoing tissue damage
35
ongoing tissue damage is often caused by
the inflammatory cells in the infiltrate a chronic inflammatory infiltrate fibrosis
36
Chronic inflammation can be caused by one of the following three ways:
Persistent infections Immune-mediated inflammatory diseases Prolonged exposure to potentially toxic agents, either exogenous or endogenous
37
Caused by microorganisms that are difficult to eradicate like mycobacteria and certain viruses, fungi, and parasites
Persistent infections
38
Organisms that are difficult to eradicte often evoke an immune reaction called_________ and the inflammatory response takes a specific pattwrn called
delayed-type hypersensitivity, granulomatous reaction.
39
chronic inflammation cause that is group of diseases that are caused by excessive and inappropriate activation of the immune system
Immune-mediated inflammatory diseases
40
conditions where immune reactions develop against the individual’s own tissu
autoimmune diseases
41
Examplew of toxic agents, either exogenous or endogenous that cause chronic imflammation
silica causing silicosis | endogenous toxic lipid component causeing atherosclerosis
42
3 Morphologic Features of Chronic Inflammation
Mononuclear Cell Infiltration Tissue Destruction or Necrosis Proliferative Changes
43
2 Types of Chronic inflammation
Non-specific | Specific
44
An example of this inflammation is chronic ulcer when the irritant substance produces a reaction with formation of granulation tissue and healing by fibrosis
Non specific
45
Inflammation where the injurious agent causes a characteristic histologic tissue response like in tuberculosis
Specific
46
Two classifications of inflammation according to descriptive histologic features
1. Chronic non-specific inflammation | 2. Chronic granulomatous inflammation
47
This is characterized by non-specific inflammatory cell infiltration (e.g. chronic osteomyelitis, lung abscess)
Chronic non-specific inflammation
48
This is characterized by formation of granulomas (e.g. tuberculosis, leprosy, syphilis, etc)
Chronic granulomatous inflammation
49
A distinctive pattern of chronic inflammation encountered in a limited number of infectious and some non-infectious conditions.
Granulomatous Inflammation
50
This is a cellular attempt to contain an offending agent that is difficult to eradicate, involving strong activation of T lymphocytes leading to macrophage activation causing injury to normal tissue
granuloma
51
granuloma morphology
1 mm tiny circumscribed lesiom composed predominantly of modified macropahages (epitheliod cells) rimmed at the periphery by lymphoid cells
52
Granuloma that have a large mass of cytoplasm containing 20 or more small nuclei arranged either peripherally.
Langhans-type giant cell
53
Granuloma that have a large mass of cytoplasm containing 20 or more small nuclei arranged either haphazardly.
foreign body-type giant cell