[LE1] Lecture 3 Flashcards
(124 cards)
Development is more than just differentiation; it also includes ______________________ to construct the organized body form.
cell-to-cell communication
What are the 2 general populations of cells in developing embryos?
Epithelial cells and Mesenchymal cells
- adhere to one another and can form sheets and tubes
- similar to the epithelium that lines an organ
- surface ectoderm
Epithelial cells
Migrate individually and form extensive extracellular matrices that can keep individual cells separate
Mesenchymal cells
Organs form by the interaction of __________________ and __________________ involves the cell surface
epithelium and mesenchyme
Tissue that produces a signal that changes behavior or other tissues
INDUCER
Signals are __________ factors secreted in the extracellular space
paracrine
Cells of tissues being induced
RESPONDER
Must have the _______________ protein for the inducing factor
receptor competent
The ability to respond to a specific inductive signal
COMPETENCE
Not a passive state but an __________ acquired condition
active
A ___________________ is a requirement for the responder to be induced
competent factor
In a developing eye, the optic vesicle is the ___________ for the lens
inducer
The two factors needed to induce the lens
otx2 and pax 6
Secrete what two to bind with lmaf and sox3 to develop the eye.
Fgf8 and BMP4
You need pax6 in _________________ only, not in optic vesicle
surface ectoderm
The malformation of the iris
Iridia
True or False:
The inducer can be induced
True
True or False:
Structure does not need to be fully differentiated to have a function
True
The optic vesicle responds and becomes the optic cup. The Wall differentiates into two layers: _______________________________
pigmented and neural retina
___________________ is aka the notochord
Chordamesoderm
The notochord is secreting factors to have the 2 differentiate (late gastrula):
neural plate and epidermis
TYPES OF INDUCTION:
Definition based on the type of response
Instructive induction
Permissive induction
TYPES OF INDUCTION:
Definition based on distance between cell producing a morphogen and cells responding to morphogen
Paracrine system
Juxtacrine system
Autocrine system