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Immuno Mem !! > Lect 9 > Flashcards

Lect 9 Flashcards

(90 cards)

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1
Q

Primary T cell deficiency

A 
CD 40 ligand
CD 40
CD 3 gamma
CD8
ZAP 70
CA channel
CD 25
STAT 5B
ITK
DOCK8
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2
Q

signal transduction extracellular domain recognizes?

A

soluble ligands

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3
Q

nuclear receptors intracellular transcription factors recognize?

A

lipid soluble ligands that cross plasma membrane

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4
Q

clustering of receptors

A

cross linking

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5
Q

initiates signal transduction

A

phosphorylation of tyr, ser, thre

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6
Q

phosphatses

A

play inhibitory role

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7
Q

alternative signal tranduction

A
  • addition of ubiquitin molecules
  • addition of lipids
  • acetylation and metyhation of N tail of histones… modulate gene expression
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8
Q

non receptor tyr kinase based receptor

A

integrin Src kinases

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9
Q

EGF insulin

A

tyrosine kinase receptor

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10
Q

Vitamin D glucocorticoids

A

goes to nucleus for transcrtiption of hormone gene

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11
Q

chemokines prostglandins

A

GPCR ligand… beta sheet transmembrane protein

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12
Q

delta delta like notch ligands

A

transcritipn of notch target gene

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13
Q

Src family

A

c-src, lyn, fyn, lck

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14
Q

Syk family

A

zap 70, syk SH2

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15
Q

tec family

A

tec, btk, and Itk PH

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16
Q

bind phosphotyrosing containing peptides

A

SH2

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17
Q

recognize proline rich stretches in polypeptides

A

SH3

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18
Q

PIP3 or other lipids

A

PH

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19
Q

adaptor protiens

A

promote the assembly of complexes… often contain proline rich stetches that can bind SH3… may contain tyrosines for SH2

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20
Q

LAT

A

linker for the acitavtiaon of T cells, integral membrane protein shtat functions as adaptor

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21
Q

BLNK

A

B cells Linker

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22
Q

CADS and SLP 76

A

two cytosolic adaptors

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23
Q

LAT gets phosphorylated and recirites?

A

PH C and the GADS adaptor

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24
Q

SLP76 what domain?

A

SH3, associated with GADS and recurits VAV, which is a tyrosine phosphorlated

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25
VAV
actin cytoskeletal rearrangmetn
26
PLC gamma binds to?
SH2
27
PLC gamma activates
Ca signaling
28
inhibitory signal found on B cells and myeloid cells
FC gamma RII B
29
Ag binding and clustering results in?
Src family activation for TCR and BCR
30
SRC family does what?
phospholates ITAM
31
SYK recognize
phosphorylated tyrosine and have tandem SH2 domain.. and can bind ITAM
32
TCR complex made up of?
6X ginaling chains and 10X ITAMs
33
ITAMs interpret
affinity
34
Weak TCR signal
positive slection f T cells in the thymus
35
strong TCR signals
apoptosis
36
What is co receptor on B cells
complement receptor type 2 (CR2/CD21)
37
inhibitory T cell receptor
CTLA 4
38
inhibitory receptors in B
CD 22 and Fc gamma RIIB
39
costimulation in activation of T cells
CD 28 and CD80/86
40
APC CD80/86
naïve T cell CD 28 Th cell activation
41
TCR without presence of costimulation
MHC class II in absence of co receptors induces cell death or anergy
42
CD40L
CD40 T cell activation w/ TCR and CD28
43
TCR associated signaling molecules
CD3 and zeta non covalently linked to TCR | -mediated by charges residues in their transmmbrane regions
44
IG associated signaling molecues
Ig alpha and beta
45
Th signal transduction
CD4
46
cytotoxic signal transduction
CD8
47
Th antigen recognition
TCR
48
SIgnal transduction for Th
CD3, CD 28.. link via B7-1/B7-2 on APC
49
Th adhision
LFA-1.... via ICAM on APC
50
When does CD 4 appear
antigen presenting MCH II
51
WHen does CD 8 appear?
MHC class I from all nucleated cells
52
CD28 signal transduction
ligand B7-1.B7-2 on antigetn preseing cells
53
CTLA 4 negative regualation signal transduction
ligand B7-1/B7-2 on antigen presenting cells
54
PD1 negative regulation signal trnasduction
PDL1/PDL2 antigen presenting cell, tissue cells, tumor cells
55
LFA for adhesion
ligand ICAM1 from antigen presning cells or epithelium
56
CD8 is composed of?
two related chains, CD8 alpha and beta
57
CD4 is composed of?
four extracellular Ig like domains, a hydrophobic transmembrane region, and a highly basic cytoplasmic tail 38aa long
58
CD 4 Binds to TCR
causing Lck and ZAP 70
59
ZAP 70with CD4 causes
phosphorylation of LAT and SLP 76
60
Cd4 associated Lck becomes activated?
CD3 and zeta chains
61
what binds to zeta?
ZAP 70
62
ZAP 70 activates
LAT
63
Lat becomes docking site for?
PLC gamma 1
64
PLC gamma 1 activates
RAS and MAP kinases
65
activated PI3 brings?
PIP3 from PIP2
66
PDK1 binds to
PIP3
67
PDK1 activates
Akt to cause cell survival by inactivating Bcl-2
68
PKC theta associateds with
TCR intracellularly
69
Lck activates?
ZAP 70 upon Ag recognition
70
ZAP 70 phosphorlates
LAT
71
LAT binds
Grb 2 adaptor
72
Grb2 docks/
GTP/GDP exchange factor SOS
73
SOS converts
RAS GDP to RAS GTP
74
RAS GTP activates
MAP kinase and ERK... which activates AP1
75
actaveated LAT binds
PLC gamma 1
76
LAT was activated by?
ZAP 70
77
PLC gamma 1 hydorlyzes membrane
PIP2 to gnereate IP3 and DAG
78
IP3 stimulates
increase in cytosolic Ca relased from ER
79
DAG activates
PKC
80
PCK and Ca induce
numerous other cellular responses
81
Ag stimulate T cells transactivated?
IL2 gene
82
PKC is important for?
NF kappa B
83
NF kappa B is?
p50p60 heterodimer incatevated by Ikappa B
84
PKC phosphorylates
IkB and activated NF kappa B is translocated into thenucleus
85
AP1 and NFkB regulate?
gene expression
86
NFAT alone elcits?
expression of a distinct set of anergy inducing genes
87
production of anergy genes?
inhibit T cell function at different levels and induce a status of T cell unresponsiveness
88
TCR signal 1 and CD28 signal 2 induce
different singaling pathways that result in the activation of several transctiption factors
89
NFAT cooperates with ?
AP1 and NFkB to induce gene expression of prouctive immune response
90
TCR singal 1 occurs
in the absence of co stimulation ca mediated signals iduce that acitavtes of NFAT only

Immuno Mem !! (7 decks)

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