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Immuno Mem !! > Lect6 > Flashcards

Lect6 Flashcards

(61 cards)

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1
Q

What determines Ig type?

A

Heavy chain

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2
Q

What are the variety of heavy chains?

A

u, delta, gamma, epsilon and alpha

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3
Q

ImM has an extra?

A

constant region that is transmembrane bind to B cells

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4
Q

Papin breaks IgG into/

A

two Fab, one Fc

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5
Q

Pepsin breaks IgG into/

A

one bivalent, and peptide fragments

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6
Q

What six things are in the Ig superfamily?

A

IgG, TCR, MHC CLass I, CD4, CD28, ICAM1

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7
Q

What is the Ig super family for?

A

recognition, binding or adhesion

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8
Q

T cell Ag binding site

A

three cer V alpha, three CDRs V betas

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9
Q

Igs bind?

A

proteins, lipids, polysaccharides, small chemicals

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10
Q

Who disociates easier?

A

Ig

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11
Q

Ig rate?

A

rapid on, variable off

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12
Q

T cel rate?

A

slow on, slow off

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13
Q

What are CDR regions composed of?

A

two antiparallel beta strands, which form two beta pleated sheets held together by disulfide bonds

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14
Q

What creates a neoantigenic determinant?

A

proteolysis

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15
Q

Pre B cell production

A

cytoplamic u heavy, and pre B receptor

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16
Q

immature B cell

A

membrane IgM

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17
Q

matuer B cell

A

membrane IgM, IgD

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18
Q

Activated B cell

A

Low rate Ig secretion; heavy chain isotype switching; affinity maturation

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19
Q

antibody secreting cell

A

high rate Ig secretion; reduced membrane Ig

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20
Q

B cell changes from membrane to secreted

A

change from B cell receptor to effector fucntion

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21
Q

Isotype swithcing

A

each isotype serves a different set of effector functions

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22
Q

mucsoal secretions

A

IgA

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23
Q

plamsa

A

IgM

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24
Q

mast cells

A

IgE

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25
tissue
IgG
26
What has J chains/
A and M
27
What has a scretory section
A
28
150kDa
IgG
29
vascular and extravascular
IgG
30
most abundant immnoglobulin in blood
IgG
31
bulk of immunity to most bloodborne pathogens
IgG
32
Only Ab to cross placenta
IgG, passes humoral response
33
IgG structure
two heavy gamma chains with either two kappa or two lambda light chaings
34
IgG has four different subclasses
IgG1, IgG2, IgG3, IgG4
35
What makes an IgG subclass different/
slightly different sequences in their H chains that result in differnt functions
36
FCRn recruits?
IgG to fetal circulation eventually catabolizes
37
present in external secretions
IgA
38
420 kDa Dimer
IgA, in serum as 170kDa four polypeptide chain
39
IgA structure
in addition to H alpha chain, the secreted have tow poly peptides... one J chain, one secretory, held together by disulfide bonds
40
SC
is part of the poly Ig receptor involved in teh transepithelial transport of exocrin IgA an stabalizes IgA against proteolytic degrdation
41
Iga is synthesized/
locally by plamsa cells in mammary and salivary glands, along respiratory, Gi and GU tract
42
What is first line of defense against microbial invaders?
IgA
43
First Ab produced by B cell
IgM
44
BCR
IgM
45
IgM expresses what on B cell
two u H chains and two L chains
46
Blood IgM
fiver four chain units held together by disulfide bridges
47
What dose J chain do?
initiates polymerization of the subunits during secretion from a plasma cell
48
900 kDa
IGm
49
found primarily in bloodstreem
IgM, high affinity, effective in removing microbes
50
Low quntities
IgD
51
Ag recetor B lymphocyte primary function
IgD
52
B cells express ?
IgM and D
53
What Ag interactis with IgMandB on B cell it is?
internalized, processed and presented to T helper cells
54
very low levels, acute inflammation, infection oby worms and allergic reactions
IgE
55
binds to mast cells
IgE
56
What happens when Ag binds to IgE on mast cell?
releases triggers relase of mediators
57
alpha
IgA
58
gamma
IgG
59
u
IgM
60
e
IgE
61
delta
IgD

Immuno Mem !! (7 decks)

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