Lect8

Question 1

CD4… attach to non variant portion of MHC

Answer 1

T helper cells

Question 2

CD8…attach to non variant protion of MHC

Answer 2

cytotoxic T cells

Question 3

Cytotoxic T cells

Answer 3

MHC class I

Question 4

T helper cells

Answer 4

MHC class II

Question 5

MHC class II are expressed on?

Answer 5

dendritic cells, Mo, and B cells… APCs

Question 6

MHC I are expressed on?

Answer 6

all nucleated cells

Question 7

T cell activation leads to?

Answer 7

IL2… which controls clonal expansion

Question 8

TH1

Answer 8

help Mo get rd of intracellular organisms. activate ctyotoxi T cells

Question 9

TH2

Answer 9

mainly involved in helping B cells develop memeroy cells

Question 10

Th2 cells important for B cell proliferation

Answer 10

IL-4

Question 11

TCR composed of?

Answer 11

two polypeptide alpha beta make up C and V

Question 12

rare TCR

Answer 12

gamma and delta- broader specificity to include HSPs and phospholipids

Question 13

genes coding for TCR polypeptide chains

Answer 13

members of the Ig super family

Question 14

part of TCR complex

Answer 14

CD3

Question 15

what is CD3 made up of?

Answer 15

gamma, delta, epsilon

Question 16

two separate signaling molecules for TCR

Answer 16

zeta zeta

Question 17

Class I genes encode a polymorphic heavy chain… expressed on surface of all nucleated cells.

Answer 17

HLA-A, B , C… combines beta2, microglobulin

Question 18

Class II genes encode?

Answer 18

HLA DP, DR, D, DQ. composed of two dissimilar polymorphic polypeptide chains, alpha and beta, which contribute to peptide binding grooove

Question 19

WHat is the binding site for MHC I and II

Answer 19

polymorphic region

Question 20

class one made up of?

Answer 20

polymorphic alpha and beta 2 macroglobulin

-alpha chain is glycosalated

Question 21

Class II composed of?

Answer 21

polypeptide alpha and beta… both are glycosolated

Question 22

anchor residues are on?

Answer 22

the peptides

Question 23

anchor residues bind to?

Answer 23

residues in the class I and II grooves and vary for MHC alleles

Question 24

Which can hold longer peptides?

Answer 24

class II because it is open

Question 25

Expression of MHC is modulated by?

Answer 25

cytokines

Question 26

WHat binds to MHC I?

Answer 26

viruses that have infected the cell.. endogenous pathway

Question 27

MHC II recognize?

Answer 27

pathogens taken from the environment

Question 28

clonal expansion and differentiation into effector T cells

Answer 28

Naïve T cell activation

Question 29

macrophage activation cell mediated immunity

Answer 29

effect T cell response

Question 30

B cell activation and antibody production humoral immunity

Answer 30

Effector T cell response

Question 31

What increases expression of MHC II on ddendritic cells?

Answer 31

IFN gamma

Question 32

Costimulatiors of dendritic cells and macrophages

Answer 32

TLR ligands. IFN gamma, T cells CD40, CD 40L

Question 33

Principal functions of dendritic cells

Answer 33

initiation of T cell resposnes to proteins

Question 34

macrophages induced MHC II expression by?

Answer 34

IFN gamma

Question 35

B lymphocyte class II MHC expression increased by?

Answer 35

IL 4

Question 36

Costimulatiors of B lyphocytes

Answer 36

induced T cell antigen receptor cross linking

Question 37

Principal function of B lymphocytes

Answer 37

antigen presentation to CD4+ helper T cells in humoral immune responses

Question 38

Activated dendritic cells express high levels of?

Answer 38

B7, ICAM-1, IL 12

Question 39

NK cells produce what during innate immune reactions to microbes or by T cells during adaptive immune response?

Answer 39

IFN gamma

Question 40

IFN gamma stimulates?

Answer 40

class II MHC and CD4

Question 41

what effects experession of class I MHC and activation of CD8

Answer 41

IFN gamma and type I interferons

Question 42

recognize cell associated and NOT soluble Ag

Answer 42

alpha beta T cells

Question 43

extra cellular Ag recognition

Answer 43

CD4

Question 44

intracellular Ag recognition

Answer 44

CD8

Question 45

Virus that is in cytoplasm and synthesized,

Answer 45

goes to proteosomes

Question 46

Peptides goes to ?

Answer 46

ER where it assembles peptide class I complex.. is taken to surface

Question 47

editing mechanism works to ensure the presentation of only the protein fragments most relevant for elcicinting an immune repsone

Answer 47

HLA DM

Question 48

What causes the dissociation of CLIP?

Answer 48

DM from the peptide biding groove of MHC II

Question 49

what stabilizes and prevents degradation of the empty MHC II

Answer 49

HLA DM

Question 50

facidliates the binding of antigen fragments to the open stabilized bidining groove

Answer 50

HLA DM

Question 51

WHere is MHC II synthesized

Answer 51

ER

Question 52

CLIP stays on MHC II until

Answer 52

peptide binds and goes to surface to be expressed

Question 53

MHC I peptides are produced from

Answer 53

cytoplasmic proteosomes

Question 54

MHC II peptes come from?

Answer 54

endosomal and lysosomal protsases

Question 55

site of MHC I peptide loading

Answer 55

ER

Question 56

site of MHC II peptide loading

Answer 56

specialized vesicles

Question 57

molecules involved in transport of peptides and loading of mHC moleduels class II

Answer 57

invariant chain and DM

Question 58

Class I loading moleduls

Answer 58

TAP