Lecture 13

Question 1

Ag recognition by T cell induces?

Answer 1

IL12… proliferation differntation into effector or memroty

Question 2

CD4 effector T cells

Answer 2

activate macrophages

Question 3

signal 1

Answer 3

ag recognition

Question 4

signal 2

Answer 4

costimulation

Question 5

signal 3

Answer 5

cytokines

Question 6

naïve T cells NEED

Answer 6

DCs

Question 7

Effector T cells can use?

Answer 7

Mo and B cells

Question 8

what are inhibitory molecules?

Answer 8

CLTA4 and CD45

Question 9

Activating co stimulatory

Answer 9

CD44, CD43

Question 10

superantigens bind?

Answer 10

simultandeously MHC class ii and the V reiogn of the beta subunit of the TCR
-not a peptides, bind to a specific region of TCR… glue
-massive amounts of cytokines produced, may lead to shock…
staphylococcal entertoxins

Question 11

WHat help with costimulation of T cells?

Answer 11

B7

Question 12

Activated APCs produce what? by cd28

Answer 12

IL12…. differentiate into effector cells, signal 3

Question 13

cell survival cd28

Answer 13

Bcl-Xl, Bcl-2

Question 14

cell proliferation cd28

Answer 14

IL2, cyclins up, cell cycle inhibitors down

Question 15

CD28 binds to what?

Answer 15

b71 and b72 or cd80/86… or ICOSL

Question 16

What is the coinhibitor of CD 28, they compete?

Answer 16

CTLA 4

Question 17

What else can CD 80 bind to?

Answer 17

PDL1… programed cell death, but 80 inhibits

Question 18

ICOS competes with CD 28 for?

Answer 18

ICOS L

Question 19

What induces expression of CD 40 on APCs?

Answer 19

Ag recognition

Question 20

CD40L binding will induce expression of?

Answer 20

B7 and the secretion of cytokines

Question 21

What reduces expression of S1PR1?

Answer 21

CD69, this causes cells to stay in LN and proliferate to effector and memory cells

Question 22

Expression is increased and enables activated T cells to respond to the growth promoting IL2

Answer 22

CD25, IL2Ralpha

Question 23

Expression of CD40L enables activated T cells too?

Answer 23

help macrophages and B cells… positive feed back mechanism to DCs for more proliferation

Question 24

CTLA4

Answer 24

regulates t cell response

Question 25

Co stimulatory T cells produce?

Answer 25

IL 4 , IL 5 and IFN gamma

Question 26

What induces anti apoptotic BCL 2

Answer 26

IL2

Question 27

stimulates cell cycles progression by inhibiting

Answer 27

p27

Question 28

If this is missing reg T cells will not develop

Answer 28

IL2

Question 29

T bet

Answer 29

drives differentiation twd development of effector cells in CD 4

Question 30

What promotes the gnereation of memory cells?

Answer 30

Blimp1

Question 31

WHat allows memory cells to not die and slowly reproduce?

Answer 31

IL7 and IL 15

Question 32

WHat are markers for T cells?

Answer 32

IL7R, CD45, CD27

Question 33

T cells express the chemokine receptor CCR7 and the L selectin for home maintain to Lns

Answer 33

central memory T Cell

Question 34

home to mucosal tissue

Answer 34

effector T cells... do not proliferate, but do produe cytokines IFN gamma or become cytotoxic

Question 35

IL 2 starvation triggers?

Answer 35

mitochondrial apoptosis

Question 36

death receptors

Answer 36

TNFRI and Fas