lecture 1 pathways to men and women

Question 1

how many autosomes?

Answer 1

22 pairs

Question 2

men

Answer 2

XY

Question 3

women

Answer 3

XX

Question 4

sex determined when

Answer 4

fertilisation

Question 5

eggs carry which choromosome?

Answer 5

X

Question 6

when is the genetic sex male

Answer 6

when there is a why chromosome

Question 7

sperm carry?

Answer 7

X or Y

Question 8

is SRY highly conserved?

Answer 8

yes

Question 9

region Y choromosome carries

Answer 9

SRY region

Question 10

XY females, how?

Answer 10

missing SRY box

Question 11

week for foprmation of gonads?

Answer 11

3-4

Question 12

what forms either side of the dorsal aorta to form genital ridges?

Answer 12

2 mesenchymal knots

Question 13

gonads develop from? trilaminar

Answer 13

mesoderm

Question 14

what makes the gametes?

Answer 14

germ cells

Question 15

where do the germ cell migrate from

Answer 15

hind gut

Question 16

where do the germ cell migrate to?

Answer 16

gonad

Question 17

what done germ cells express

Answer 17

SRY

Question 18

how many waves of cellular migration is there?

Answer 18

3

Question 19

2nd wave of migration?

Answer 19

epithelial wave

Question 20

on the edge of the developing gonad

Answer 20

columnar epithelium

Question 21

what is the columnar epithelium also called?

Answer 21

coelomic epithelia

Question 22

where does the coelamic epithelia migrate to?

Answer 22

cortex of the developing gonad

Question 23

in males what part of the gonad develops into the testis?

Answer 23

medulla

Question 24

in males what degenerates?

Answer 24

cortex

Question 25

what does coelomic epithlelia form?

Answer 25

testes cords

Question 26

what do the testes cords terminate to form?

Answer 26

rete testis

Question 27

in females what does the coelomic epithelia do?

Answer 27

surround the primordial germ cells

Question 28

what does the coelomic epithelia penetrate in males?

Answer 28

mesenchyme

Question 29

what are the prospermatogonia the precurser of?

Answer 29

sertoli cell

Question 30

what does SRY initiate the expression of?

Answer 30

SOX9

Question 31

something special about SRY

Answer 31

self sustaining

Question 32

what does SOX9 initiate?

Answer 32

prostoglandin D2

Question 33

prostoglandin D2 drives?

Answer 33

the production of FGF9

Question 34

what promotes the action of SOX9?

Answer 34

FGF9 and prostoglandin D2

Question 35

what is FGF9?

Answer 35

growth hormone

Question 36

SOX9 inhibits?

Answer 36

FOX ligand 2

Question 37

what is FOX 2 for?

Answer 37

production of the internal female genitalia

Question 38

what does SOX9 promote?

Answer 38

AMH

Question 39

first wave?

Answer 39

primordial germ cells

Question 40

3rd wave

Answer 40

cells from the mesenephric duct

Question 41

what causes the 3rd wave?

Answer 41

FGF9

Question 42

what do the cells of the 3rd wave form?

Answer 42

internal genitalia

Question 43

male internal genitalia?

Answer 43

rete testic, vas deferens and epididymis

Question 44

in males what does the mesonephric primordia make?

Answer 44

leydig cells, vascular tissue and myoid cells

Question 45

in females what does the mesonephric primorpdia make

Answer 45

theca cells and vascular tissue

Question 46

what happens when there us no SRY?

Answer 46

FOX ligand 2 drives the production of WNT4 which instructs the ceolomic epithelium to make a granulosa cell

Question 47

what determines weather PGD will be a spermatogonia or oogonia?

Answer 47

environment

Question 48

in males what does the internal genitalia form from?

Answer 48

wolffian duct

Question 49

in females what does the internal genetalia form from?

Answer 49

mullerian tissue

Question 50

what does the mullerian duct produce?

Answer 50

urethra, carvix, ovarian duct and upper vagina

Question 51

what does AMH cause?

Answer 51

regression of the mullerian duct

Question 52

what does androgen do

Answer 52

causes the wolffian duct to predominate