Lecture 10 Innate host resistance Flashcards Preview

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Flashcards in Lecture 10 Innate host resistance Deck (22):
1

Lack of resistance to a disease

susceptibility

2

Ability to ward off disease

Immunity

3

Recognizes foreign substances or microbes and acts to neutralize or destroy them 

Immune system 

4

Defense agains any pathogen 

innate immunity

5

Immunity or resistance to a specific pathogen 

Adaptive immunity

6

Anitmicrobial secretions in mucus membranes

  • Lysozyme
    • hydrolyzes bond connecting sugars in peptidoglycan
  • Lactoferrin
    •  secreted by activated macrophages and PMNs
    • sequesters iron from plasma
  • Lactoperoxidase
    • Produces superoxide radicals

7

Paneth cells produce ___ and ___

  • lysozyme
  • cryptins

8

What is in tears 

  • Lysozyme
  • Lactoferrin
  • secretory IgA

9

function of Antimicrobial peptides (AMPs)

Inhibit cell wall synthesis, form pores in the plasma membrane that cause lysis; and destroy DNA and RNA 

10

First class of cationic peptides

  • linear, alpha-helical peptides that lack cysteine amino acid residues
    • e.g. cathelicidin

11

second class of cationic peptides 

  • defensins, peptides that are open-ended, rich in arginine and cysteine, and disulfide linked
    • alpha and beta 

12

Third class of cationic peptides

  • Larger peptides that are enriched for specific amino acids and exhibit regular structural repeats
    • e.g. histatin 

13

The complement system is composed of greater than ___ serum proteins

30 

14

what are the three major activities of complement system 

  • defending against bacterial infections
  • bridging innate and adaptive immunity
  • disposing of wastes 

15

what are the three major activation pathways fo the complement system

  • Alternative
  • Lectin
  • Classical

16

Which complement pathway is involved in nonspecific defenses against intravascular invasion by bacteria/fungi

Alternative Complement Pathway 

17

The alternative complement pathway begins with the activation of 

C3

18

The alternative complement pathway is dependent on 

interaction of complement with repetitive structures on pathogens 

19

The Alternative complement pathway results in formation of 

Membrane attack complex 

20

The classical complement pathway is usually dependent on 

antigen-antibody interactions (thus it is part of acquired iimmunity and not as fast as other pathways)

21

The lectin complement pathway begins with

activation of C3 and lectin binding 

22

The lectin complement pathway is dependent on 

  • interaction of host mannose binding protein (MBP) with pathogen surfaces 
    • enhances phagocytosis