Lecture 11- Gyn Oncology Flashcards Preview

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Flashcards in Lecture 11- Gyn Oncology Deck (52):
1

What is the # cells/ tumor actively involved in cell division that excludes G0 phase?

Growth fraction

2

What decreases with tumor growth?

Growth fraction (less O2 and vascular supply)

3

What type of radiation produces free radicals and disrupts cancer cells DNA & ability to divide?

Ionizing radiation therapy

4

What is a benign vulvar disease that is 2ndary to irritant dermatitis and has the CC of progressive vulvar pruritis/ burning. Will have diffuse erythema w/ red or red-brown plaques

Lichen simplex chronicus

5

Name that benign vulvar disease-Wickham striae, patchy erythema. Ctyology: WBCs, few bacteria. recurrence is likely

Lichen planus

6

Name that benign vulvar disease: PE: Atrophic, thin, hyperkeartotic patches. Have a risk of squamous cell CA. (parchment paper) Hx: dyspareunia, pruritus

lichen sclerosis

7

Are vulvar diseases with the work "lichen" in front of them malignant or benign?

Benign

8

What stage of VIN is associated w/ the presence of condyloma acuminata?

VIN 1

9

What does VIN, usual type look like? Commonly seen in smokers

Dusky red or white lesions, patchy

10

What is VIN?

Vulvar intraepithelial neoplasm

11

What does VIN, differentiated type look like?

Warty papule, ulcer, hyperderatotic

12

Which type of VIN is more at risk of developing into invasive carcinoma and needs to be completely excised?

VIN, differentiated type

13

What type of vulvar disease is fiery red w/ white hyperkeratotic areas and is treated w/ wide local excision or vulvectomy? Patients have hx of breast or colon cancer

Vulvar Paget's

14

What is the most common type of vulvar cancer?

Squamous cell carcinoma

15

What is VAIN?

Vaginal intraepithelial neoplasm

16

What is a rare pediatric vaginal cancer that is a grape like mass at the introitus?

Sarcoma botryoides

17

What drug therapy can help treat hyperplasia associated with uterine neoplasia?

Progestin therapy
Medorxyprogesterone acetate (10-14 days/month) or daily (no periods)

18

Which type of endometrial cancer are a majority estrogen dependent; majority are adrenCA.

Type I

19

What type of endometrical cancer is unrreleated to estrogen or endometrial hyperplasia. Will typical have an atrophic endometrium

type II endometrial cancer (poorer prognosis)

20

What tyep of endometrical cancer is unrreleated to estrogen or endometrial hyperplasia.

type II endometrial cancer (poorer prognosis)

21

Most is the most common side effect of antineoplastic drugs?

Myelosupression

22

How do you treat VIN, usual type?

Use acetic wash and do multiple site biopsies
do a complete excision to r/o SCC

23

If a women over 40 has a inflamed bartholin's gland what should you do?

Get a biopsy

24

If a women has ASC-US and a negative HPV what do you do?

Pap in 1 year

25

for post menopausal women, how thick should the endometrial lining be?

less than 4 mm

26

for uterine hyperplasia with atypia what do you?

D & C

27

What is a corpus luteum cysts associated w/?

Missed menses

28

What hormone does corpus luteum release?

Progesterone

29

What is clomiphene used for?

Ovulation induction

30

What type cyst is associated with : IUP, clomiphene & gonadotropin ovulation induction

Theca lutein cyst

31

What are the 2 types of non-functional neoplasms?

Epithelial cell tumors
Germ cell tumors (termatoma)

32

What are 2 types of functional neoplasms?

Stomal cell (grnaulosa theca cell- estrogen)
Sertoli-Leydig (androgenic)

33

is there a screening tool for ovarian CA?

No, very hard to detect in early stages

34

Levels of ________ are used to track ovarian CA.

CA-125

35

What phase of the cell cycle is not affected by chemo or radiation?

G0 phase

36

What are the 6 types of benign vulvar diseases?

1. lichen simplex chronicus
2. lichen planus
3. lichen sclerosis
4. psoriasis
5. Dermatitis- Eczema
6. Dermatitis- Seborrheic

37

What is a pale lesion with oily scale or crust that doesn't usually need a biopsy?

Seborrheic dermatitis

38

What disease should you avoid speculum use because there is pain with insertion of objects into the vagina?

Localized vulvodynia

39

What is the prescription for vulvar lipomas and fibromas?

excision

40

With lichen simplex chronicus, what should you do if there is no response to Rx within 3 months?

biopsy

41

According to Dr. B, this PE is most characteristic of Lichen planus

Wickham striae

42

According to Dr. B, this PE is most characteristic of Lichen sclerosis

parchment like epithelium

43

What is the way to diagnose the usual type of VIN and how is this a different diagnosis from the other two forms of VIN?

Usual type: colposcopy with acetic wash and multiple site biopsies

VIN 1 and differentiated just do a biopsy

44

What age range is vulvar cancer most associated with?

70-80 y/o

45

What do you need to rule out before diagnosis of VAIN?

cervical neoplasia
invasive vaginal carcinoma

46

What other problem is associated with Uterine neoplasia?

AUB

47

What are risk factors for uterine neoplasia?

FHx breast, colon, other gyn CA
Chronic anovulation
Unopposed estrogen (Endogenous/Exogenous)

48

What are the two types of endometrial cancer?

I: majority estrogen dependent; andenocarcinoma
II: unrelated to estrogen or endometrial hyperplasia

49

What are 3 types of non-neoplastic functional ovarian cysts?

corpus luteum cysts
follicular cysts
theca lutein cyst

50

Stromal cells, a type of benign ovarian neoplasm, are estrogenic or androgenic?

Estrogenic

51

What CA has the highest mortality of all gyn CA?

ovarian

52

What are two types of proteomic research for ovarian CA?

Tumor vaccine (introduce own tumor cells to immune system)
Proteins encoded by genome (deliver normal P53 gene to tumor to inhibit growth)