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ObGyn Lecture > Lecture 11- Gyn Oncology > Flashcards

Lecture 11- Gyn Oncology Flashcards

1
Q

What is the # cells/ tumor actively involved in cell division that excludes G0 phase?

A

Growth fraction

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2
Q

What decreases with tumor growth?

A

Growth fraction (less O2 and vascular supply)

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3
Q

What type of radiation produces free radicals and disrupts cancer cells DNA & ability to divide?

A

Ionizing radiation therapy

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4
Q

What is a benign vulvar disease that is 2ndary to irritant dermatitis and has the CC of progressive vulvar pruritis/ burning. Will have diffuse erythema w/ red or red-brown plaques

A

Lichen simplex chronicus

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5
Q

Name that benign vulvar disease-Wickham striae, patchy erythema. Ctyology: WBCs, few bacteria. recurrence is likely

A

Lichen planus

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6
Q

Name that benign vulvar disease: PE: Atrophic, thin, hyperkeartotic patches. Have a risk of squamous cell CA. (parchment paper) Hx: dyspareunia, pruritus

A

lichen sclerosis

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7
Q

Are vulvar diseases with the work “lichen” in front of them malignant or benign?

A

Benign

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8
Q

What stage of VIN is associated w/ the presence of condyloma acuminata?

A

VIN 1

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9
Q

What does VIN, usual type look like? Commonly seen in smokers

A

Dusky red or white lesions, patchy

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10
Q

What is VIN?

A

Vulvar intraepithelial neoplasm

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11
Q

What does VIN, differentiated type look like?

A

Warty papule, ulcer, hyperderatotic

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12
Q

Which type of VIN is more at risk of developing into invasive carcinoma and needs to be completely excised?

A

VIN, differentiated type

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13
Q

What type of vulvar disease is fiery red w/ white hyperkeratotic areas and is treated w/ wide local excision or vulvectomy? Patients have hx of breast or colon cancer

A

Vulvar Paget’s

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14
Q

What is the most common type of vulvar cancer?

A

Squamous cell carcinoma

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15
Q

What is VAIN?

A

Vaginal intraepithelial neoplasm

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16
Q

What is a rare pediatric vaginal cancer that is a grape like mass at the introitus?

A

Sarcoma botryoides

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17
Q

What drug therapy can help treat hyperplasia associated with uterine neoplasia?

A 
Progestin therapy
Medorxyprogesterone acetate (10-14 days/month) or daily (no periods)
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18
Q

Which type of endometrial cancer are a majority estrogen dependent; majority are adrenCA.

A

Type I

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19
Q

What type of endometrical cancer is unrreleated to estrogen or endometrial hyperplasia. Will typical have an atrophic endometrium

A

type II endometrial cancer (poorer prognosis)

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20
Q

What tyep of endometrical cancer is unrreleated to estrogen or endometrial hyperplasia.

A

type II endometrial cancer (poorer prognosis)

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21
Q

Most is the most common side effect of antineoplastic drugs?

A

Myelosupression

22
Q

How do you treat VIN, usual type?

A

Use acetic wash and do multiple site biopsies

do a complete excision to r/o SCC

23
Q

If a women over 40 has a inflamed bartholin’s gland what should you do?

A

Get a biopsy

24
Q

If a women has ASC-US and a negative HPV what do you do?

A

Pap in 1 year

25
Q

for post menopausal women, how thick should the endometrial lining be?

A

less than 4 mm

26
Q

for uterine hyperplasia with atypia what do you?

A

D & C

27
Q

What is a corpus luteum cysts associated w/?

A

Missed menses

28
Q

What hormone does corpus luteum release?

A

Progesterone

29
Q

What is clomiphene used for?

A

Ovulation induction

30
Q

What type cyst is associated with : IUP, clomiphene & gonadotropin ovulation induction

A

Theca lutein cyst

31
Q

What are the 2 types of non-functional neoplasms?

A

Epithelial cell tumors

Germ cell tumors (termatoma)

32
Q

What are 2 types of functional neoplasms?

A 
Stomal cell (grnaulosa theca cell- estrogen) 
Sertoli-Leydig (androgenic)
33
Q

is there a screening tool for ovarian CA?

A

No, very hard to detect in early stages

34
Q

Levels of ________ are used to track ovarian CA.

A

CA-125

35
Q

What phase of the cell cycle is not affected by chemo or radiation?

A

G0 phase

36
Q

What are the 6 types of benign vulvar diseases?

A
  1. lichen simplex chronicus
  2. lichen planus
  3. lichen sclerosis
  4. psoriasis
  5. Dermatitis- Eczema
  6. Dermatitis- Seborrheic
37
Q

What is a pale lesion with oily scale or crust that doesn’t usually need a biopsy?

A

Seborrheic dermatitis

38
Q

What disease should you avoid speculum use because there is pain with insertion of objects into the vagina?

A

Localized vulvodynia

39
Q

What is the prescription for vulvar lipomas and fibromas?

A

excision

40
Q

With lichen simplex chronicus, what should you do if there is no response to Rx within 3 months?

A

biopsy

41
Q

According to Dr. B, this PE is most characteristic of Lichen planus

A

Wickham striae

42
Q

According to Dr. B, this PE is most characteristic of Lichen sclerosis

A

parchment like epithelium

43
Q

What is the way to diagnose the usual type of VIN and how is this a different diagnosis from the other two forms of VIN?

A

Usual type: colposcopy with acetic wash and multiple site biopsies

VIN 1 and differentiated just do a biopsy

44
Q

What age range is vulvar cancer most associated with?

A

70-80 y/o

45
Q

What do you need to rule out before diagnosis of VAIN?

A

cervical neoplasia

invasive vaginal carcinoma

46
Q

What other problem is associated with Uterine neoplasia?

A

AUB

47
Q

What are risk factors for uterine neoplasia?

A

FHx breast, colon, other gyn CA
Chronic anovulation
Unopposed estrogen (Endogenous/Exogenous)

48
Q

What are the two types of endometrial cancer?

A

I: majority estrogen dependent; andenocarcinoma
II: unrelated to estrogen or endometrial hyperplasia

49
Q

What are 3 types of non-neoplastic functional ovarian cysts?

A

corpus luteum cysts
follicular cysts
theca lutein cyst

50
Q

Stromal cells, a type of benign ovarian neoplasm, are estrogenic or androgenic?

A

Estrogenic

51
Q

What CA has the highest mortality of all gyn CA?

A

ovarian

52
Q

What are two types of proteomic research for ovarian CA?

A 
Tumor vaccine (introduce own tumor cells to immune system)
Proteins encoded by genome (deliver normal P53 gene to tumor to inhibit growth)

ObGyn Lecture (21 decks)

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