Lecture 13- Antibiotics pt.2

Question 1

How do antibiotics that target folic acid work?

Answer 1

Competitive inhibition to block enzyme that creates folic acid

Question 2

What do Sulfonamides do?

What do they target?

Answer 2

• Competes with natural PABA and inhibit DNA replication
• Folic acid

Question 3

How do antibiotics that target cell membrane work?

Answer 3

Bind to LPS of gram negative bacteria

Question 4

What is bad about Polymyxins?

What do they target?

Answer 4

• Toxic to the kidneys
• Cell membrane

Question 5

How do antibiotics that target DNA/RNA work?

Answer 5

Target DNA gyrase in gram negative

Target topoisomerase in gram positive

Question 6

What is bad about Quinolones?

What do they target?

Answer 6

Not recommended during pregnancy/for children

DNA/RNA

Question 7

How do Rifamycins work?

What do they target?

Answer 7

• Block RNA polymerase
• DNA/RNA

Question 8

Most antifungals are:

Answer 8

Fungistatic

Question 9

How do Polyenes (antifungal) work?

Answer 9

Bind ergosterol in membrane

Question 10

How do Macrolides (antifungal) work?

Answer 10

Treat systemic fungal infections

Question 11

How do Azoles (antifungal) work?

Answer 11

Inhibit ergosterol synthesis

Question 12

How do Euchinocandins (antifungal) work?

Answer 12

Damage cell wall of fungi

Question 13

How do Flucytosine (antifungal) work?

Answer 13

Inhibit DNA replication

Question 14

How do Quinine (Antiprotozoa) work?

Answer 14

Used for malaria parasite

Question 15

What do mebendazole (antihelminth) work?

Answer 15

Inhibits metabolism in eggs

Question 16

How do Praziquantel (antihelminth) work?

Answer 16

Paralyze fluke/tapeworms

Question 17

How do antiviral groups that prevent entry work?

Answer 17

Bind receptor to prevent fusion with host

Question 18

How do antivirals that prevent release work?

Answer 18

Inhibits neuraminidase for budding/releasing

Question 19

How do antivirals that prevent transcription/translation work?

What virus are they mainly used for?

Answer 19

Makes fake nucleotides that are incorporated and stops transcription.

Those exposed to HIV

Question 20

How do antivirals that prevent maturation work

Answer 20

Protease that stops viral assembly