Lecture 16 - Preterm Birth Flashcards Preview

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Flashcards in Lecture 16 - Preterm Birth Deck (12):
1

Preterm labour definition?

labour before 37 weeks gestation, very preterm < 32 weeks

2

Mechanisms of spontaneous preterm birth?

intrauterine stretch (related to CAP, cytokines and prostaglandins, as well as membrane disruption), endocrine maturation, intrauterine hemorrhage, intrauterine infection

3

Preterm activation?

fetal genome, uterine strss, fetal HPA axis, abnormal membrane rupture, cervical changes (infection leading to early inflammation

4

Placentation causes of preterm birth?

growth of fetus, poor attachment (bleeding), progesterone, prostaglandins

5

Problems of preterm birth?

fetal health, fetal outcomes, maternal co-morbidity, breech risk, complicated c section, recurrence risk

6

Iatrogenic premature birht?

maternal disease (preeclampsia), FGR; other types being sponataneous

7

Taking history: risk of preterm birth?

previous PTB, smoking, cervical surgery, maternal disease, antepartum bleeding

8

Cervix and PTB?

small cervix length leads to greater risk

9

Fetal fibronectin?

biological glue beween amniotic and chorion membranes, high concentrations in 1st trimester nad late pregnancy only, normally low in between

10

Tocolysis?

suppresses preterm labour, Ca channel and oxytocin receptor blockers

11

Antenatal corticosteroids (betamethasone)?

prevention of neonatal death from respiratory distress syndrome

12

Magnesium sulphate?

neuroprotection