Lecture 2 - Hypothalamus/Pituitary 2 Flashcards Preview

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Flashcards in Lecture 2 - Hypothalamus/Pituitary 2 Deck (7)
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1
Q

Oestrogen signalling?

A

classical (cytoplasmic receptor -> nucleus) and non-classical (involvement of signalling cascade)

2
Q

CREB?

A

enzyme inhibited by oestrogen in GnRH neurons

3
Q

Kisspeptin regulation of GnRH neuron activity during puberty?

A

positive feedback RP3V, negative feedback ARN

4
Q

Acromegaly condition?

A

increased somatotrophin and failure to decrease blood glucose in oral glucose challenge test

5
Q

Acromegaly presentations?

A

enlarged pituitary, headache, increased BP, protruding jaw and enlarged small bones (hands and feet)

6
Q

Idiopathic central precocious puberty?

A

mutation of proline into arginine, leading to prolonged intracellular signalling pathways related to kisspeptin, increasing amplitude pulse of GnRH

7
Q

Kallman syndrome?

A

GnRH deficiency leading to delayed/absent puberty and bone weakness