Lecture 17 - Thyroid Flashcards Preview

Reproduction > Lecture 17 - Thyroid > Flashcards

Flashcards in Lecture 17 - Thyroid Deck (19):
1

Normal functions of the thyroid?

normal growth & development, metabolic and oxygen, lipid and carbohydrate metabolism (body weight)

2

Embryology of thyroid?

endoderm origin, in thyroglossal duct, functional 12 weeks, independent 20 weeks,

3

Surroundings of thyroid?

recurrent pharyngeal nerves (posterior), oesophagus (to the left), superior and inferior thyroid artery, deep to sterno-hyoid muscle

4

Iodine?

150 microg/day, from salt, fish and bread, or supplements (pregnancy), deficiency leads to thyroid enlargement (Goitre)

5

Locations of Sodium-Iodide symporter?

thyroid, breast, gastric mucosa, salivary glands, cancer thyroid cells

6

Rare thyrotoxicity from overdose of thyroid supplements?

factitious thyrotoxicosis

7

Parafollicular cells?

calcitonin, linked to medullary thyroid cancer

8

Thyroid pyroxidase?

measured in hyper and hypothyroid, enzyme involved in T3 and 4 production

9

Hyperthyroid/thyrotoxicosis drug?

carbimazole

10

T4 and 3 bind to?

tissue receptors with alpha (LH, FSH, TSH and HCG) and beta subunits

11

HCG thyroid?

in pregnancy, partial stimulation of TSH receptros which leads to a normal decline in TSH, and a rise in T3 and 4

12

Iodide and TSH?

TSH stimulates increases iodide in follicular lumen, increasing endocytosis to form T4, which converts to T3 in periphery; also increases blood flow, Tg, TPO and pyroxide

13

Regulation of thyroid hormone?

TRH, TSH and T3 negatively feedback in pituitary

14

Thyrotoxicosis/hyperthyroid - symptoms?

nervousness, weight loss, heat sensitive, tachycardia, weakness

15

Thyrotoxicosis/hyperthyroid - signs?

Goitre, skin changes, tremor, eye inflammation (glycans infiltrating fat)

16

Graves Disease?

autoimmune production of antibody that stimulates TSH receptor

17

Goitre?

Hyper-functioning regions of thyroid gland, not suppressed by circulating thyroid hormone

18

Hypothyroidism symptoms?

weight gain, cold, hair loss, constipation, oedema

19

Hypothyroidism diagnosis?

low t4 and t3, high tsh; positive for TOP suggests Hashimoto's disease