Flashcards in Lecture 3 - Female Reproductive Tract I Deck (20):
Fetal oocyte production?
as primordial germ cells in yolk sac, migrate to embryonic gonadal ridge @ 6weeks gestation
Germ cell development in ovary?
differentiation into diploid oogonia, population expands via mitosis producing oocytes, undergo meiosis up till prophase of meiosis I, lie completely dormant in ovarian cortex until puberty and beyond
Primordial -> tertiary follicle progression?
decreasing in numbers each step: primordial -> primary -> secondary (85 days) -> 1 or 2 tertiary (2-3 weeks)
identifying primordial cells?
flattened granulosa cells
identifying primary cells?
granulosa cells become cuboidal (follicular wave has begun)
Identifying secondary cells?
proliferation of g cells into multiple layers with FSH receptors which act to produces oestrogen, inhibin and AMH; thecal cell presence with LH receptors, acting produce androgen
Identifying tertiary cells?
antrum formation, w follicular fluid, theca externa development
T cell turn progesterone to androgen, G cell turn androgen into oestrogen (all reversible)
Protein shell and cells?
zona pellucida, ZP1 (found in primordial), 2 and 3 added to activate follicle, filter normal sperm and prevent polyspermy
Cluster of cells surrounding oocyte within follicle?
anti-mullerian hormone, released from mature follicles to inhibit other primoridal development in follicular wave
proliferates granulosa cells
inhibits FSH, up till a peak where it positively feedsback as well as trigger LH spike causing ovulation
produced by luteal granulosa cells (along with estrogen), moves from ovary to uterus to work on endometrium and myometrium
negative feedbacks FSH @ pituitary
Parts of fllopian tubes?
fimbria, infundibulum, ampulla, isthmus
ampulla complex with heaps of foldings, wider as progresses
ciliated or secretory, responsive to steroids (increased with oestrogen
Muscular coat and other component?
inner circular, outer long (serosal coat)