Lecture 17- HIV Flashcards Preview

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Flashcards in Lecture 17- HIV Deck (2)
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1

HIV life cycle steps

1) HIV gp120 binds to helper T-cell CD4 surface molecule

2) conformational change allows the viral and CD4 membranes to fuse, emptying the viral contents into the cell

3) Reverse transcriptase converts viral RNA into viral DNA

4) The viral DNA travels into host cells nucleus, where viral protein 'integrase' integrates the DNA into the hosts DNA

5) Transcription in the cell means that viral RNA is produced from the cell for the integrated DNA

6) Assembly of the RNA into viral proteins

7) Budding of immature HIV proteins, cleavage by protease converts them to mature HIV particles

2

ART in HIV therapy

'Anti-Retroviral Treatment'
combo of three different drugs with at least 2 different targets. This doesn't cure HIV but instead keeps it at a manageable level
Drug Targets (at different point of the viral life cycle)
- Fusion (enfurvitide)
- Reverse Transcriptase (tenofovir)
- Integrase (raltegravir)
- Protease (atazanavir)