Lecture 26- Intro to Tumor Biology Flashcards Preview

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Flashcards in Lecture 26- Intro to Tumor Biology Deck (3)
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1

Differentiation is?

when cells become different to one another.
Embryo:
Early cells similar. Then they differentiate into 3 germ layers. Then cells further differentiate within these layers.

Post Embryonic:
Occurs at level of cells.
Maturation of differentiated cells from proliferative cells.

Involves
-inactivation o proliferative genes
-activation of special function genes

2

De-differentiation is?

When things go wrong.

Reversion to primitive, embryonic proliferative cells.

3

Disorders of growth

Embryo = malformations
-these occur in utero, eg) collection of abnormal blood vessels

Post-natal = abnormalities of
tissue function and tissue mass


Clinical Implications:
-Not all are disorders