LECTURE 2 | Connective Tissue Flashcards
(57 cards)
It encompasses the major structural constituents of the body
Connective tissue
Most connective tissues are derived from ____________, which form the multipotential mesenchyme from which bone, cartilage, tendons, ligaments, capsules, blood and hematopoietic cells, and lymphoid cells develop.
Mesoderm
A type of tissue that support, defense, transport, storage and repair.
Connective tissue
Connective tissue are mainly composed of?
- Extracellular elements
- Limited number of cells
In connective tissue:
• Mesenchymal
• Mucous
Embryonic CT
In connective tissue:
• Loose
• Reticular
• Adipose
• Dense irregular
• Dense regular
✓ Collagenous
✓ Elastic
Adult CT
Connective tissue:
• Supporting Tissues
✓ Cartilage
✓ Bone
• Blood
Specialized CT
It intricate network composed of an array of multidomain macromolecules organized in a cell/tissue-specific manner.
Extracellular Matrix
3 Subdivisions of Extracellular matrix
- Fibers
- Amorphous Ground Substance
- Extracellular Fluid
What are the 3 protein fibers?
- Elastic fiber
- Collagen fiber
- Reticular fiber
It is the most abundant of the fibers
Collagen fiber
A fiber in extracellular matrix that are inelastic, composed of a staggered array of the protein tropocollagen
Collagen fiber
How many different types of Collagen fibers are there?
25 different types
Where does the synthesis of collagen occurs?
It occurs in the Rough Endoplasmic Reticulum
What specific part of Rough Endoplasmic Reticulum does the specific proline and lysine residues are being hydroxylated, and hydroxylysine residues are being glycosylated?
Cisternae
In collagen fiber, it is the vesicles that convey the procollagen molecules to the Golgi apparatus for modification, mostly the addition of carbohydrate side chains.
Coatomer-coated transfer vesicles
Collagen:
molecules self-assemble, forming fibrils with 67nm characteristics banding.
Tropocollagen molecules
Type of collagen that is composed of procollagen rather than tropocollagen subunits, hence the absence of periodicity and fibril formation in this type of collagen.
Type IV collagen
Thin, branching, carbohydrate-coated fibers composed of type III collagen that form delicate networks around smooth muscle cells, certain epithelial cells, adipocytes, nerve fibers, and blood vessels.
Reticular fiber
Constitute the structural framework of certain organs, such as liver and the spleen
Reticular fiber
As a result of the carbohydrate coat, when stained with silver stain, the silver preferentially deposits on these fibers giving them a brown to black appearance in the light microscope.
Reticular fiber
A fiber which is a highly elastic that may stretched to about 150% of their resting length without breaking.
Elastic fibers
A fiber which is composed of amorphous protein, elastin, surrounded by a microfibrillar component consisting fibrillin.
Elastic fibers
The elasticity of elastin is due to its __________ content in that four __________ molecules, each belonging to a different elastin chain, form covalent desmosine crosslinks with one another.
Lysine
