Lecture 2: Predictors of Successful Aging Flashcards
What are the 3 R’s that helped Esther get to 100
Resolution
Resilience
Rescourcefulness
True of false: There is a direct relationship between $ & :) up to 80,000$
TRUE
What percentage does genetics contribute to the aging process?
20-30%
According to WHO what factors contribute to the model of successful aging? (8)
- genetics
- health and social services
- life style choices and behaviors
- psychological attributes
- life events
- socioeconomic status
- physical and social environment
- culture and gender
What are the 2 main categories of the Modern Biological Theory of Aging?
- Programmed Theory
2. Damage/Error Theory (easier to demonstrate, more papers on it in pub med)
What is the programmed theory?
Aging follows a biological timetable that depends on changes in GENE expression affecting systems responsible for maintenance, repair and defence responses
What is the damage/error theory
ENVIRONMENTAL stress to living organisms would induce cumulative damage at various levels as the cause of aging
What are the 3 sub categories of the programmed theory?
- Programmed longevity
- Endocrine theory
- Immunological theory
What is the programmed longevity theory
Aging is the result of a sequential switching on and off of certain genes with senescence (deterioration) being defined as the time when age associated deficits are manifested
What is the endocrine theory
Biological clocks (pre programmed) act through hormones to control the pace of aging. Supported by recent studies showing that INSULIN plays a key role in the hormonal regulation of aging
What is the immunological theory
The immune system is programmed to decline over time, which leads to an increased vulnerability to infectious disease and thus aging and death
What are the 5 sub categories of the damage/error theory
- Wear and tear
- Rate of living
- Cross linking
- Free radical
- Somatic DNA
What is the wear and tear theory
Cells and tissues have vital parts that wear out from repeated use resulting in aging (like an old car)
What is the rate of living theory
The greater an organism’s rate of oxygen basal metabolism, the shorter its life span
What is the cross linking theory
Accumulation of cross linked proteins would damage cells and tissues, slowing down bodily processes resulting in aging
Proposed by Johan Bjorksten in 1942
What is the free radical theory (1954)
Superoxide and other free radicals would cause damage to the macromolecular components of the cell, causing cells and eventually organs to stop functioning (sells a lot of products)
The macromolecules such as nucleic acids, lipids, sugars and proteins are susceptible to free radical attack
What is the somatic DNA theory
Aging would result from damage to the genetic integrity of the body’s cells. In particular genetic mutations and damage to mitochondrial DNA would affect the body’s cells.
According to the rate of living theory which factor would contribute more to life expectancy
Animal size or animal heart rate
Heart Rate
True of False: it has been found that restricting calories can extend life span in laboratory animals
TRUE
Is there a positive of negative relationship between heart rate and life expectancy?
Negative, slower heart rates lead to longer lives
True or False: As you age cross linking increases and the amount of oxidative modification increases
TRUE
True or False: free radicals attack the lipid membrane and proteins
TRUE
The psychological theory of aging is a theory of selective ______ with ________
The psychological theory of aging is a theory of selective optimization with compensation
According to the psychological theory of aging, successful aging = ability of an OA to adapt to?
Physical, mental and social losses in later life
